Trimethyl phosphite
Trimethyl phosphite structure
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Common Name | Trimethyl phosphite | ||
|---|---|---|---|---|
| CAS Number | 121-45-9 | Molecular Weight | 124.076 | |
| Density | 1.052 g/mL at 25 °C(lit.) | Boiling Point | 110.2±8.0 °C at 760 mmHg | |
| Molecular Formula | C3H9O3P | Melting Point | −78 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 27.8±0.0 °C | |
| Symbol |
GHS02, GHS05, GHS07 |
Signal Word | Danger | |
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Interactions of multitargeted kinase inhibitors and nucleoside drugs: Achilles heel of combination therapy?
J. Chromatogr. A. 1421 , 154-61, (2015) Multitargeted tyrosine kinase inhibitors (TKI) axitinib, pazopanib, and sunitinib are used to treat many solid tumors. Combination trials of TKIs with gemcitabine, a nucleoside anticancer drug, in pancreas, renal, lung, ovarian, and other malignancies resulte... |
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Rapid modification of the insect elicitor N-linolenoyl-glutamate via a lipoxygenase-mediated mechanism on Nicotiana attenuata leaves.
BMC Plant Biol. 10 , 164, (2010) Some plants distinguish mechanical wounding from herbivore attack by recognizing specific constituents of larval oral secretions (OS) which are introduced into plant wounds during feeding. Fatty acid-amino acid conjugates (FACs) are major constituents of Mand... |
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The functionalisation of saturated hydrocarbons--XXX. Model studies on the mechanism of some oxygenases.
Bioorg. Med. Chem. 2(4) , 259-66, (1994) In harmony with our studies on the activation of hydrocarbons by Gif chemistry, we have, in the first part of this paper, studied the mechanism of the lipoxygenase enzymes using soybean lipoxygenase as a model. We have shown with trimethyl phosphite that no f... |
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Surface characterization and platelet adhesion studies of plasma polymerized phosphite and its copolymers with dimethylsulfate.
Biomaterials 20(16) , 1439-47, (1999) Due to its capability for using a wide variety of organic and inorganic compounds as the monomer source, including those which are not polymerizable by conventional methods, plasma polymerization has been used to incorporate various functional groups onto the... |
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Trimethyl phosphite as a trap for alkoxy radicals formed from the ring opening of oxiranylcarbinyl radicals. Conversion to alkenes. Mechanistic applications to the study of C-C versus C-O ring cleavage.
J. Am. Chem. Soc. 125(11) , 3248-59, (2003) Trimethyl phosphite, (MeO)(3)P, is introduced as an efficient and selective trap in oxiranylcarbinyl radical (2) systems, formed from haloepoxides 8-13 under thermal AIBN/n-Bu(3)SnH conditions at about 80 degrees C. Initially, the transformations of 8-13, in ... |
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Teratological evaluation of trimethyl phosphite in the rat.
Toxicol. Appl. Pharmacol. 72(1) , 119-23, (1984) Trimethyl phosphite (TMP) is an organophosphorus alkylating agent used primarily in the synthesis of organophosphate compounds. To evaluate teratogenic potential, TMP was administered by gavage to pregnant rats at rates of 16, 49, or 164 mg/kg/day, on gestati... |
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Matrix isolation infrared and DFT study of the trimethyl phosphite-hydrogen chloride interaction: hydrogen bonding versus nucleophilic substitution.
J. Phys. Chem. A 116(49) , 12014-23, (2012) Trimethyl phosphite (TMPhite) and hydrogen chloride (HCl), when separately codeposited in a N(2) matrix, yielded a hydrogen bonded adduct, which was evidenced by shifts in the vibrational frequencies of the TMPhite and HCl submolecules. The structure and ener... |
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Electron-rich heteroaroylphosphonates and their reaction with trimethyl phosphite.
Org. Biomol. Chem. 6(3) , 577-85, (2008) Dialkyl heteroaroylphosphonates based on thiophene, pyrrole or furan have been prepared and their reactions with trimethyl phosphite investigated. Deoxygenation of the carbonyl groups in these heteroaroylphosphonates occurs to give carbene intermediates, whic... |
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Correlation between the rate order and the number of molecules in the reaction of trimethyl phosphite with water in acetonitrile solvent.
J. Phys. Chem. A 114(43) , 11699-707, (2010) Density functional theory calculations of the title reaction, P(OCH₃)₃ + (H₂O)(n) in CH₃CN, were conducted, where n is the number of water molecules. Two routes, the routes suggested by (A) Aksnes and (B) Arbuzov, were traced with various n values. Both route... |
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[Studies on the reactions of unsaturated chloride polyether polyol with trimethyl phosphite by FTIR].
Guang Pu Xue Yu Guang Pu Fen Xi 24(11) , 1334-7, (2004) The reactions of unsaturated chloride polyether polyol with trimethyl phosphite have been studied by FTIR, which was prepared by copolymerization of ethanediol, allyl glycidyl ether and epoxychloropropane. The experimental results showed that the reaction inc... |