GERANYLGERANIOL
GERANYLGERANIOL structure
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Common Name | GERANYLGERANIOL | ||
|---|---|---|---|---|
| CAS Number | 24034-73-9 | Molecular Weight | 290.48300 | |
| Density | 0.88 g/cm3 | Boiling Point | 397.1ºC at 760 mmHg | |
| Molecular Formula | C20H34O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 128.3ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Polyunsaturated Branched-Chain Fatty Acid Geranylgeranoic Acid Induces Unfolded Protein Response in Human Hepatoma Cells.
PLoS ONE 10 , e0132761, (2015) The acyclic diterpenoid acid geranylgeranoic acid (GGA) has been reported to induce autophagic cell death in several human hepatoma-derived cell lines; however, the molecular mechanism for this remains unknown. In the present study, several diterpenoids were ... |
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PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation.
Cancer Cell Int. 15 , 27, (2015) PDZ binding-kinase (PBK) (also named T-lymphokine-activated killer cell-originated protein kinase (TOPK)), a serine/threonine kinase, is tightly controlled in normal tissues but elevated in many tumors, and functions in tumorigenesis and metastasis. However, ... |
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Novel High Content Screen Detects Compounds That Promote Neurite Regeneration from Cochlear Spiral Ganglion Neurons.
Sci. Rep. 5 , 15960, (2015) The bipolar spiral ganglion neurons (SGN) carry sound information from cochlear hair cells to the brain. After noise, antibiotic or toxic insult to the cochlea, damage to SGN and/or hair cells causes hearing impairment. Damage ranges from fiber and synapse de... |
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Novel salvage pathway utilizing farnesol and geranylgeraniol for protein isoprenylation.
Biochem. Biophys. Res. Commun. 237(3) , 483-7, (1997)
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Rapid identification of cysteine-linked isoprenyl groups by metabolic labeling with [3H]farnesol and [3H]geranylgeraniol.
Methods Mol. Biol. 116 , 107-23, (1999)
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Inhibition of HMG CoA reductase reveals an unexpected role for cholesterol during PGC migration in the mouse.
BMC Dev. Biol. 8 , 120, (2008) Primordial germ cells (PGCs) are the embryonic precursors of the sperm and eggs. Environmental or genetic defects that alter PGC development can impair fertility or cause formation of germ cell tumors.We demonstrate a novel role for cholesterol during germ ce... |
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Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway.
J. Biol. Chem. 288(38) , 27444-55, (2013) Mammalian cells can use exogenous isoprenols to generate isoprenoid diphosphate substrates for protein isoprenylation, but the mechanism, efficiency, and biological importance of this process are not known. We developed mass spectrometry-based methods using c... |
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Activity of mevalonate pathway inhibitors against breast and ovarian cancers in the ATP-based tumour chemosensitivity assay.
BMC Biochem. 9 , 38, (2009) Previous data suggest that lipophilic statins such as fluvastatin and N-bisphosphonates such as zoledronic acid, both inhibitors of the mevalonate metabolic pathway, have anti-cancer effects in vitro and in patients. We have examined the effect of fluvastatin... |
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Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts.
J. Oral. Pathol. Med. 43(9) , 711-21, (2014) The mevalonate pathway (MVP) and the anti-angiogenic effect of bisphosphonates have been shown to play a role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ). This study determined the effect of the bisphosphonate, zoledronic ac... |
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Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of STAT3 signaling pathway.
Cancer Lett. 360(2) , 280-93, (2015) Aberrant activation of signal transducer and activator of transcription 3 (STAT3) is frequently observed in multiple myeloma (MM) cancer and can upregulate the expression of several genes involved in proliferation, survival, metastasis, and angiogenesis. The ... |