TN-16
TN-16 structure
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Common Name | TN-16 | ||
|---|---|---|---|---|
| CAS Number | 33016-12-5 | Molecular Weight | 306.35800 | |
| Density | 1.249g/cm3 | Boiling Point | 532.7ºC at 760 mmHg | |
| Molecular Formula | C19H18N2O2 | Melting Point | 182-185 °C | |
| MSDS | Chinese USA | Flash Point | 195.5ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
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CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.
J. Cell Sci. 128 , 4572-87, (2015) Although it is generally accepted that chromatin containing the histone H3 variant CENP-A is an epigenetic mark maintaining centromere identity, the pathways leading to the formation and maintenance of centromere chromatin remain unclear. We previously genera... |
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Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug.
FEBS Lett. 155(2) , 273-6, (1983) An antitumor drug, 3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16) inhibited the assembly of porcine brain microtubules in vitro. The assembly induced by taxol was also suppressed by the drug. However, the latter required much higher concentrati... |
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Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity.
Biochem. Biophys. Res. Commun. 296(2) , 328-36, (2002) Fas ligand (FasL) has been implicated in cytotoxic T lymphocyte (CTL)- and natural killer (NK) cell-mediated cytotoxicity. In the present study, we investigated the localization of FasL in murine CTL and NK cells. Immunocytochemical staining showed that FasL ... |
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Effects of low concentration of vinblastine on the anchorage-independent growth and in vitro invasion of human renal carcinoma cell lines.
Cancer Lett. 69(2) , 85-91, (1993) A study was conducted on the effect of vinblastine (VBL), an anti-mitotic drug that is commonly employed in the treatment of human renal cell carcinoma. When VBL was added to serum-free cultures of the ACHN and NT cell lines (both lines are of human renal car... |