TN-16
TN-16 structure
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Common Name | TN-16 | ||
|---|---|---|---|---|
| CAS Number | 33016-12-5 | Molecular Weight | 306.35800 | |
| Density | 1.249g/cm3 | Boiling Point | 532.7ºC at 760 mmHg | |
| Molecular Formula | C19H18N2O2 | Melting Point | 182-185 °C | |
| MSDS | Chinese USA | Flash Point | 195.5ºC | |
| Symbol |
GHS07, GHS09 |
Signal Word | Warning | |
Use of TN-16TN-16 is a potent inhibitor of microtubule polymerization with IC50 of 0.4-1.7 µM[1]. |
| Name | tn-16 |
|---|---|
| Synonym | More Synonyms |
| Description | TN-16 is a potent inhibitor of microtubule polymerization with IC50 of 0.4-1.7 µM[1]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.249g/cm3 |
|---|---|
| Boiling Point | 532.7ºC at 760 mmHg |
| Melting Point | 182-185 °C |
| Molecular Formula | C19H18N2O2 |
| Molecular Weight | 306.35800 |
| Flash Point | 195.5ºC |
| Exact Mass | 306.13700 |
| PSA | 58.20000 |
| LogP | 3.08450 |
| Index of Refraction | 1.648 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H317-H400 |
| Precautionary Statements | P273-P280 |
| Hazard Codes | Xi |
| Risk Phrases | 43-50/53 |
| Safety Phrases | 36/37-60-61 |
| RIDADR | UN 3077 9 / PGIII |
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CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.
J. Cell Sci. 128 , 4572-87, (2015) Although it is generally accepted that chromatin containing the histone H3 variant CENP-A is an epigenetic mark maintaining centromere identity, the pathways leading to the formation and maintenance o... |
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Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug.
FEBS Lett. 155(2) , 273-6, (1983) An antitumor drug, 3-(1-anilinoethylidene)-5-benzylpyrrolidine-2,4-dione (TN-16) inhibited the assembly of porcine brain microtubules in vitro. The assembly induced by taxol was also suppressed by the... |
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Localization of Fas ligand in cytoplasmic granules of CD8+ cytotoxic T lymphocytes and natural killer cells: participation of Fas ligand in granule exocytosis model of cytotoxicity.
Biochem. Biophys. Res. Commun. 296(2) , 328-36, (2002) Fas ligand (FasL) has been implicated in cytotoxic T lymphocyte (CTL)- and natural killer (NK) cell-mediated cytotoxicity. In the present study, we investigated the localization of FasL in murine CTL ... |
| 2,3`-ANHYDROTHYMIDINE-D3 |
| 3-[1-(Phenylamino)ethylidene]-5-(phenylmethyl)-2,4-pyrrolidinedione |