Doxofylline
Doxofylline structure
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Common Name | Doxofylline | ||
|---|---|---|---|---|
| CAS Number | 69975-86-6 | Molecular Weight | 266.253 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 505.2±53.0 °C at 760 mmHg | |
| Molecular Formula | C11H14N4O4 | Melting Point | 144-146ºC | |
| MSDS | USA | Flash Point | 259.3±30.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors.
Arch. Int. Pharmacodyn. Ther. 295 , 221-37, (1988) In the present study the interaction of doxofylline, a new antiasthmatic drug, with A1- and A2-adenosine receptors of the guinea-pig brain and rat striatum was investigated in comparison with known methylxanthine derivatives. Inhibition studies of N6-cyclohex... |
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Doxofylline in rat brain in relation to locomotor activity.
Drug Metab. Dispos. 17(4) , 437-40, (1989) Doxofylline is a new xanthine derivative with significant bronchodilatatory activity. We have studied in HPLC the distribution of doxofylline in various areas of rat brain (cortex, cerebellum, limbic system) and its activity on the central nervous system by u... |
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The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients.
Aliment. Pharmacol. Ther. 4(6) , 643-9, (1990) The aim of this study was to compare the effects upon gastric secretion of therapeutic doses of aminophylline, with doxofylline, a new xanthine derivative proposed for the treatment of chronic asthma. Twelve patients with endoscopically-proven healed duodenal... |
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Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease.
Expert Opin. Pharmacother. 10(14) , 2343-56, (2009) Doxofylline, a methylxanthine derivative, has recently drawn attention because of its better safety profile and similar efficacy over the most widely prescribed analogue, theophylline, indicated for asthma and chronic obstructive pulmonary disease.This articl... |
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The challenge for security and privacy services in distributed health settings.
Stud. Health Technol. Inform. 134 , 113-25, (2008) The health care sector is quickly exploiting Information and Communication Technologies towards the provision of e-health services. According to recent surveys, one of the most severe restraining factors for the proliferation of e-health is the (lack of) secu... |
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To study the efficacy and safety of doxophylline and theophylline in bronchial asthma.
J. Clin. Diagn. Res. 9(4) , FC05-8, (2015) Asthma is a non communicable chronic disease prevalent all over the world. Two commonly used methylxanthines, theophylline and doxofylline were compared in the study in stable asthmatic patients at recommended doses by various spirometric lung function tests ... |
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Comparative study of the efficacy and safety of theophylline and doxofylline in patients with bronchial asthma and chronic obstructive pulmonary disease.
J. Basic Clin. Physiol. Pharmacol. 26(5) , 443-51, (2015) Bronchial asthma and chronic obstructive pulmonary disease (COPD) are the major obstructive disorders that may contribute to the severity in individual patients. The present study was designed to compare the efficacy and safety of theophylline and doxofylline... |
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Assessment of montelukast, doxofylline, and tiotropium with budesonide for the treatment of asthma: which is the best among the second-line treatment? A randomized trial.
Clin. Ther. 37(2) , 418-26, (2015) Data comparing various second-line treatments for asthma with subjective and objective assessment are lacking. This study aimed to compare the efficacy and safety of montelukast, doxofylline, and tiotropium with a low-dose budesonide in patients with mild to ... |