Doxofylline

Modify Date: 2024-01-02 23:33:03

Doxofylline structure	Common Name	Doxofylline
	CAS Number	69975-86-6	Molecular Weight	266.253
	Density	1.6±0.1 g/cm3	Boiling Point	505.2±53.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₄N₄O₄	Melting Point	144-146ºC
	MSDS	USA	Flash Point	259.3±30.9 °C
	Symbol	GHS07	Signal Word	Warning

Use of Doxofylline

Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.

Name	7-(1,3-dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
Synonym	More Synonyms

Description	Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology
Target	Adenosine A1 receptor, phosphodiesterase IV[1]
References	[1]. Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10(14):2343-56.

Density	1.6±0.1 g/cm3
Boiling Point	505.2±53.0 °C at 760 mmHg
Melting Point	144-146ºC
Molecular Formula	C₁₁H₁₄N₄O₄
Molecular Weight	266.253
Flash Point	259.3±30.9 °C
Exact Mass	266.101501
PSA	80.28000
LogP	-0.70
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.700
Water Solubility	Soluble

Doxofylline MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH5135000

CHEMICAL NAME :: Theophylline, 7-(1,3-dioxolan-2-ylmethyl)-

CAS REGISTRY NUMBER :: 69975-86-6

BEILSTEIN REFERENCE NO. :: 0561195

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H14-N4-O4

MOLECULAR WEIGHT :: 266.29

WISWESSER LINE NOTATION :: T56 BN DN FNVNVJ F1 H1 B1- BT5O COTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 965 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4868186

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 426 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 315 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 841 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,201,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 396 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4187308

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 216 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 36,201,1981

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26-S36/37
RIDADR	NONH for all modes of transport

Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors.

Arch. Int. Pharmacodyn. Ther. 295 , 221-37, (1988)

In the present study the interaction of doxofylline, a new antiasthmatic drug, with A1- and A2-adenosine receptors of the guinea-pig brain and rat striatum was investigated in comparison with known me...

Doxofylline in rat brain in relation to locomotor activity.

Drug Metab. Dispos. 17(4) , 437-40, (1989)

Doxofylline is a new xanthine derivative with significant bronchodilatatory activity. We have studied in HPLC the distribution of doxofylline in various areas of rat brain (cortex, cerebellum, limbic ...

The effect of intravenous doxofylline or aminophylline on gastric secretion in duodenal ulcer patients.

Aliment. Pharmacol. Ther. 4(6) , 643-9, (1990)

The aim of this study was to compare the effects upon gastric secretion of therapeutic doses of aminophylline, with doxofylline, a new xanthine derivative proposed for the treatment of chronic asthma....

Maxivent

Doxofilina [INN-Spanish]

Doxofylline

1H-Purine-2,6-dione, 7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-

Ansimar

7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

Ventax

Doxofyllinum [INN-Latin]

7-(1,3-dioxolan-2-ylmethyl)theophylline

doxophylline

EINECS 274-239-6

ABC 12/3

Dioxyfilline

2-(7'-theophyllinemethyl)-1,3-dioxolane

7-(1,3-Dioxolan-2-ylmethyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

7-(1,3-dioxolan-2-yl-methyl)3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

MFCD00865218

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Doxofylline
Price: ￥198.0/250mg ￥348.0/25g ￥108.0/5g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Doxofylline
Price: $300.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Doxofylline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Doxofylline
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Doxofylline
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Doxofylline

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Doxofylline Biological Activity

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ACUTE TOXICITY DATA

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