2-Amino-5-chloropyridine
2-Amino-5-chloropyridine structure
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Common Name | 2-Amino-5-chloropyridine | ||
|---|---|---|---|---|
| CAS Number | 1072-98-6 | Molecular Weight | 128.560 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 257.8±0.0 °C at 760 mmHg | |
| Molecular Formula | C5H5ClN2 | Melting Point | 135-138 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 94.7±21.8 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Simultaneous determination of zopiclone and its degradation product and main impurity (2-amino-5-chloropyridine) by micellar liquid chromatography with time-programmed fluorescence detection: preliminary investigation for biological monitoring.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 907 , 49-55, (2012) A simple and reliable HPLC method was developed and validated for the simultaneous determination of the hypnotic drug, zopiclone (ZPC) and its degradation product and main impurity, 2-amino-5-chloropyridine (ACP). The analyses were carried out on BDS Hypersil... |
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Capillary electrophoretic enantioselective determination of zopiclone and its impurities.
Electrophoresis 33(11) , 1606-12, (2012) A capillary electrophoretic enantioselective method with UV detection was developed and validated for the simultaneous quantification of zopiclone enantiomers and its impurities, zopiclone-N-oxide enantiomers, and 2-amino-5-chloropyridine, in tablets. The ana... |
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Degradation of zopiclone during storage of spiked and authentic whole blood and matching dried blood spots.
Int. J. Legal Med. 127(1) , 69-76, (2013) Z-drugs such as zopiclone are increasingly involved in forensic cases. Its degradation occurs in solvents and biological fluids. It is assumed that hydrolysis largely accounts for the breakdown of zopiclone in aqueous media. Therefore, a stability study in bl... |
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Detection of 2-amino-5-chloropyridine in urine as a parameter of zopiclone (Imovane) intake using HPLC with diode array detection.
J. Anal. Toxicol. 21(3) , 208-12, (1997) A qualitative screening technique was developed for the detection of 2-amino-5-chloropyridine, a newly identified decomposition product of zopiclone and metabolites after alkaline hydrolysis of urine samples. The method was elaborated using a standard operati... |
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Stability tests of zopiclone in whole blood.
Forensic Sci. Int. 200(1-3) , 130-5, (2010) Zopiclone is a common drug in forensic cases and it is frequently analyzed in biological materials using different analytical methods. Zopiclone is unstable in certain solvents and depending on storage conditions unstable in biological fluids; however its sta... |
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Zopiclone misuse: an update from Dublin.
Drug Alcohol Rev. 26(1) , 83-5, (2007) The prevalence of zopiclone misuse in clients attending a methadone maintenance programme in Dublin through detection of its degradation product, 2-amino-5-chloropyridine (ACP) on urinalysis is outlined. Urine samples from all 158 clients were tested for the ... |
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FTIR, FT-Raman spectra and ab initio DFT vibrational analysis of 2-amino-5-chloropyridine.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 64(3) , 586-94, (2006) The FTIR and FT-Raman spectra of 2-amino-5-chloropyridine (ACP) has been recorded in the region 4000-400 and 3500-100 cm-1, respectively. The optimized geometry, frequency and intensity of the vibrational bands of ACP were obtained by the ab initio and densit... |
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A method for the rapid detection of the zopiclone degradation product 2-amino-5-chloropyridine.
Sci. Justice 39(4) , 253-6, (1999) Zopiclone (Zimovane) is a cyclopyrrolone compound which exhibits hypnotic and sedative effects while also exhibiting anticonvulsant and muscle relaxant activities. The detection and quantification of zopiclone is difficult. It has a high molecular weight comp... |