Capecitabine
Capecitabine structure
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Common Name | Capecitabine | ||
|---|---|---|---|---|
| CAS Number | 154361-50-9 | Molecular Weight | 359.350 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 517.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C15H22FN3O6 | Melting Point | 110-121°C | |
| MSDS | Chinese USA | Flash Point | 266.8±32.9 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Risk factors for bowel dysfunction after sphincter-preserving rectal cancer surgery: a prospective study using the Memorial Sloan Kettering Cancer Center bowel function instrument.
Dis. Colon Rectum 57(8) , 958-66, (2014) Until recently, no studies have prospectively evaluated bowel function after sphincter-preserving surgery for rectal cancer with the use of a validated bowel function scoring system.The aim of this study was to investigate possible risk factors for altered bo... |
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[A case of S-1/CDDP-resistant recurrent gastric cancer responsive to capecitabine/CDDP].
Gan To Kagaku Ryoho. 41(5) , 649-51, (2014) We present a case of recurrent gastric cancer in which stable disease status was achieved for four months due to treatment with capecitabine/cisplatin (CDDP)after the failure of multiple anticancer drugs including S-1/CDDP. A 67-year-old man was diagnosed wit... |
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Genetic markers of toxicity from capecitabine and other fluorouracil-based regimens: investigation in the QUASAR2 study, systematic review, and meta-analysis.
J. Clin. Oncol. 32(10) , 1031-9, (2014) Fluourouracil (FU) is a mainstay of chemotherapy, although toxicities are common. Genetic biomarkers have been used to predict these adverse events, but their utility is uncertain.We tested candidate polymorphisms identified from a systematic literature searc... |
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Cardiotoxicity in cancer patients treated with 5-fluorouracil or capecitabine: a systematic review of incidence, manifestations and predisposing factors.
Cancer Treat. Rev. 39(8) , 974-84, (2013) To systematically review the incidence, manifestations and predisposing factors for cardiovascular toxicity in cancer patients treated with systemic 5-fluorouracil or capecitabine.We searched PubMed, EMBASE and Web of science for studies with ≥ 20 cancer pati... |
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[Effect of capecitabine therapy on the blood levels of antiepileptic drugs - report of two cases].
Gan To Kagaku Ryoho. 41(4) , 527-30, (2014) We report the cases of 2 breast cancer patients who received capecitabine(CAP)and concomitant anticonvulsant therapy with either phenytoin(PHT)or valproate(VPA)for brain metastasis. The effect of CAP on the blood levels of the 2 anticonvulsants was different ... |
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[A case of primary duodenal cancer recurrence successfully treated with CapeOX therapy].
Gan To Kagaku Ryoho. 41(4) , 495-8, (2014) A 55-year-old man was admitted to our hospital because of nausea and vomiting. An endoscopic examination and computed tomography(CT)scan revealed a duodenal tumor. A biopsy confirmed a diagnosis of primary duodenal adenocarcinoma. A pancreaticoduodenectomy an... |
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[Efficacy of AboundTM for hand-foot syndrome caused by capecitabine].
Gan To Kagaku Ryoho. 40(12) , 2457-9, (2013) Hand-foot syndrome( HFS) has been reported to be the most common adverse effect of capecitabine, with an incidence of more than 50%. AboundTM, containing β-hydroxy-β-methyl butyric acid( HMB), L-glutamine, and L-arginine is effective in the treatment of decub... |
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[A case of metastatic breast carcinoma of the cervical muscles].
Gan To Kagaku Ryoho. 40(12) , 2405-7, (2013) A 57-year-old woman was referred to another hospital with bilateral breast masses. Incisional biopsy findings indicated bilateral breast invasive lobular carcinoma, with positive estrogen receptor(ER)status and negative human epidermal growth factor receptor ... |
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[Recurrent gastric cancer treated with fourth-line chemotherapy consisting of capecitabine and cisplatin leading to partial response].
Gan To Kagaku Ryoho. 40(12) , 2265-7, (2013) A 70-year-old man with advanced gastric cancer was treated with neoadjuvant chemotherapy consisting of S-1 plus cisplatin( CDDP). He exhibited symptoms of cerebral infarction during the second course of chemotherapy. Distal gastrectomy was performed and the h... |
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[A case of HER2-positive advanced gastric cancer successfully treated with a combination of capecitabine, cisplatin, and trastuzumab as first-line chemotherapy].
Gan To Kagaku Ryoho. 40(12) , 2253-5, (2013) We report a case of human epidermal growth factor receptor(HER)2-positive advanced gastric cancer successfully treated with a combination of capecitabine, cisplatin(CDDP), and trastuzumab as first-line chemotherapy. A 66-year-old woman diagnosed as having adv... |