Paclitaxel
Paclitaxel structure
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Common Name | Paclitaxel | ||
|---|---|---|---|---|
| CAS Number | 33069-62-4 | Molecular Weight | 853.906 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 957.1±65.0 °C at 760 mmHg | |
| Molecular Formula | C47H51NO14 | Melting Point | 213 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 532.6±34.3 °C | |
| Symbol |
GHS05, GHS07, GHS08 |
Signal Word | Danger | |
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Deacetyl-mycoepoxydiene, isolated from plant endophytic fungi Phomosis sp. demonstrates anti-microtubule activity in MCF-7 cells.
Biomed. Pharmacother. 69 , 82-9, (2015) Deacetyl-mycoepoxydiene (DM), a novel secondary metabolite produced by the plant endophytic fungi Phomosis sp., induced the reorganization of cytoskeleton in actively growing MCF-7 cells by promoting polymerization of tubulin. DM could induce cell cycle arres... |
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Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption.
PLoS ONE 9(7) , e101824, (2014) Desmosomes are perturbed in a number of disease states - including genetic disorders, autoimmune and bacterial diseases. Here, we report unexpected changes in other cell-cell adhesion structures upon loss of desmosome function. We found that perturbation of d... |
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Control of cytoplasmic dynein force production and processivity by its C-terminal domain.
Nat. Commun. 6 , 6206, (2015) Cytoplasmic dynein is a microtubule motor involved in cargo transport, nuclear migration and cell division. Despite structural conservation of the dynein motor domain from yeast to higher eukaryotes, the extensively studied S. cerevisiae dynein behaves distin... |
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A flipped ion pair at the dynein-microtubule interface is critical for dynein motility and ATPase activation.
J. Cell Biol. 208(2) , 211-22, (2015) Dynein is a motor protein that moves on microtubules (MTs) using the energy of adenosine triphosphate (ATP) hydrolysis. To understand its motility mechanism, it is crucial to know how the signal of MT binding is transmitted to the ATPase domain to enhance ATP... |
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Control of microtubule trajectory within an electric field by altering surface charge density.
Sci. Rep. 5 , 7669, (2015) One of challenges for using microtubules (MTs) driven by kinesin motors in microfluidic environments is to control their direction of movement. Although applying physical biases to rectify MTs is prevalent, it has not been established as a design methodology ... |
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LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C.
PLoS ONE 10(2) , e0118662, (2015) In budding yeast, the Mitotic Exit Network (MEN) regulates anaphase promoting complex/cyclosome (APC/C) via the Dbf2-Cdc14 signaling cascade. Dbf2 kinase phosphorylates and activates Cdc14 phosphatase, which removes the inhibitory phosphorylation of the APC/C... |
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Establishment and characterization of cell lines from chromosomal instable colorectal cancer.
World J. Gastroenterol. 21(1) , 164-76, (2015) To generate novel tumor models for preclinical validation of biomarkers that allow drug response prediction and individual therapeutic decisions.Cell line establishment was conducted by both direct in vitro culturing and in vivo xenografting followed by in vi... |
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Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1.
Biochem. Pharmacol. 90(4) , 367-78, (2014) Cancer cells often become resistant to chemotherapy through a phenomenon known as multidrug resistance (MDR). Several factors are responsible for the development of MDR, preeminent among them being the accelerated drug efflux mediated by overexpression of ATP... |
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Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing.
Nat. Commun. 6 , 6410, (2015) In this study, we show that several microtubule-destabilizing agents used for decades for treatment of cancer and other diseases also sensitize cancer cells to oncolytic rhabdoviruses and improve therapeutic outcomes in resistant murine cancer models. Drug-in... |
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Control of the pericentrosomal H2O2 level by peroxiredoxin I is critical for mitotic progression.
J. Cell Biol. 210 , 23-33, (2015) Proteins associated with the centrosome play key roles in mitotic progression in mammalian cells. The activity of Cdk1-opposing phosphatases at the centrosome must be inhibited during early mitosis to prevent premature dephosphorylation of Cdh1-an activator o... |