4-Chloroindole
4-Chloroindole structure
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Common Name | 4-Chloroindole | ||
|---|---|---|---|---|
| CAS Number | 25235-85-2 | Molecular Weight | 151.593 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 293.0±13.0 °C at 760 mmHg | |
| Molecular Formula | C8H6ClN | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 158.9±5.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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The stability of the nitrosated products of indole, indole-3-acetonitrile, indole-3-carbinol and 4-chloroindole.
Food Chem. Toxicol. 27(11) , 723-30, (1989) The nitrosation rates of indole-3-acetonitrile, indole-3-carbinol, indole and 4-chloroindole and the stability of their nitrosated products were investigated. Each of the nitrosated indole compounds was directly mutagenic to Salmonella typhimurium TA100 in th... |
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In-vitro testing and the carcinogenic potential of several nitrosated indole compounds.
Cell Biol. Toxicol. 7(4) , 371-86, (1991) 4-chloro-methoxyindole is a naturally occurring compound in Vicia faba which can easily react with nitrite to form a N-nitroso compound. In this in vitro study, the potential genotoxic effects of nitrosated 4-chloro-6-methoxyindole and its structural analogue... |
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Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis.
J. Biol. Chem. 280(49) , 41090-100, (2005) The natural product indole is a substrate for cytochrome P450 2A6. Mutagenesis of P450 2A6 was done to expand its capability in the oxidization of bulky substituted indole compounds, which are not substrates for the wild-type enzyme or the double mutant L240C... |
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Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries.
J. Biotechnol. 139(1) , 12-8, (2009) Cytochrome P450 (P450) 2A6 is able to catalyze indole hydroxylation to form the blue dye indigo. The wild-type P450 2A6 enzyme was randomly mutated throughout the whole open reading frame and screened using 4-chloroindole hydroxylation, a substituted indole s... |