4-Methylbenzenesulfonhydrazide
4-Methylbenzenesulfonhydrazide structure
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Common Name | 4-Methylbenzenesulfonhydrazide | ||
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| CAS Number | 1576-35-8 | Molecular Weight | 186.232 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 340.5±35.0 °C at 760 mmHg | |
| Molecular Formula | C7H10N2O2S | Melting Point | 103-108 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 159.7±25.9 °C | |
| Symbol |
GHS02, GHS06 |
Signal Word | Danger | |
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Protecting group free glycosidations using p-toluenesulfonohydrazide donors.
Org. Lett. 10(16) , 3461-3, (2008) N'-Glycopyranosylsulfonohydrazides are introduced as glycosyl donors for protecting group free synthesis of O-glycosides, glycosyl azides, and oxazolines. Mono- and disaccharides containing a reducing terminal N-acetylglucosamine residue were condensed with p... |
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Synthesis of some p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles and their anticancer activity.
Eur. J. Med. Chem. 45(11) , 5080-5, (2010) A series of novel p-toluenesulfonyl-hydrazinothiazoles and hydrazino-bis-thiazoles derivatives (2a-f, 3a-f and 5-8) were synthesized by initial condensation of p-toluenesulfonylthiosemicarbazide 1 with a series of α-halogenocarbonyls in acetone or dimethylfor... |
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Vasoconstrictor-induced changes in renal blood flow: role of prostaglandins and histamine.
Am. J. Physiol. 254(4 Pt 2) , F470-6, (1988) The role of histamine (H) and prostaglandins (PGs) in the renal vasoconstriction prompted by a 10-min intrarenal infusion of norepinephrine (NE, 0.2 micrograms), antidiuretic hormone (ADH, 10 mU), or angiotensin II (ANG II, 0.05 micrograms) was evaluated in a... |
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Mutagenic activity of p-toluenesulfonhydrazide.
Toxicol. Ind. Health 8(6) , 369-76, (1992) Toluenesulfonhydrazide (TSH) is a high volume production chemical for which there is relatively little toxicological data. In this study, the mutagenic activity of TSH was determined in the Salmonella/mammalian microsome assay and the in vitro chromosomal abe... |
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Enantioselective synthesis of trifluoromethyl-substituted cyclopropanes.
Org. Lett. 9 , 2625, (2007) The reaction of 1-aryl-2,2,2-trifluorodiazoethanes with alkenes, catalyzed by the adamantylglycine-derived dirhodium complex Rh2(R-PTAD)4, generates trifluoromethyl-substituted cyclopropanes with high diastereoselectivity (>94%) and enantioselectivity (88->98... |
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Dipyrazolo[1,5-a:4',3'-c]pyridines - a new heterocyclic system accessed via multicomponent reaction.
Beilstein J. Org. Chem. 8 , 2223-9, (2012) The synthesis of dipyrazolo[1,5-a:4',3'-c]pyridines is described. Easily obtainable 5-alkynylpyrazole-4-carbaldehydes, p-toluenesulfonyl hydrazide, and an aldehyde or ketone containing an α-hydrogen atom were reacted in a silver triflate catalyzed multicompon... |
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Synthesis, characterization and antimicrobial activity of new 1,2,3-selenadiazoles.
Molecules 13(11) , 2740-9, (2008) The commercially available aromatic polyketones 1a-d were utilized for the synthesis of the multi-arm1,2,3-selenadiazole derivatives 3a-d. The preparation starts with the reaction between compounds 1a-d and p-toluenesulfonyl hydrazide to give the correspondin... |
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Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function.
J. Med. Chem. 50 , 755-64, (2007) The biosynthesis of methionine is an attractive antibiotic target given its importance in protein and DNA metabolism and its absence in mammals. We have performed a high-throughput screen of the methionine biosynthesis enzyme cystathionine beta-lyase (CBL) ag... |
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J. Am. Chem. Soc. 115 , 2473, (1993)
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J. Am. Chem. Soc. 114 , 966, (1992)
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