Tolfenamic acid
Tolfenamic acid structure
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Common Name | Tolfenamic acid | ||
|---|---|---|---|---|
| CAS Number | 13710-19-5 | Molecular Weight | 261.704 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 405.4±40.0 °C at 760 mmHg | |
| Molecular Formula | C14H12ClNO2 | Melting Point | 210-214°C | |
| MSDS | Chinese USA | Flash Point | 199.0±27.3 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Cholesterol lowering effect in the gall bladder of dogs by a standardized infusion of Herniaria hirsuta L.
J. Ethnopharmacol. 169 , 69-75, (2015) Infusions of Herniaria hirsuta L., Herniaria glabra L. and Herniaria fontanesii J.Gay are well known in Moroccon folk medicine for the treatment of biliary dyskinesia, (uro)lithiasis or as a diuretic. Herniariae Herba which can contain H. glabra and H. hirsut... |
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Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system.
J. Pharm. Sci. 103(8) , 2441-55, (2014) The Lipid Formulation Classification System Consortium looks to develop standardized in vitro tests and to generate much-needed performance criteria for lipid-based formulations (LBFs). This article highlights the value of performing a second, more stressful ... |
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Multiresidue determination of ten nonsteroidal anti-inflammatory drugs in bovine, porcine, and chicken liver tissues by HPLC-MS/MS.
Appl. Biochem. Biotechnol. 174(1) , 1-5, (2014) Nonsteroidal anti-inflammatory drugs (NSAIDs) are the group of drugs having the therapeutic efficacy of analgesic and antipyretic. To detect health-threatening residues of NSAIDs, a fast and easy multiresidue method based on liquid chromatography tandem mass ... |
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Veterinary drug residues in domestic and imported foods of animal origin in the Republic of Korea.
Food. Addit. Contam. Part. B. Surveill. 8 , 106-12, (2015) The Korean National Residue Programme comprises three different approaches for evaluating domestic and imported foods of animal origin: monitoring, surveillance/enforcement and an exploratory test programme. Monitoring and surveillance/enforcement testing pro... |
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Nitric oxide confers cisplatin resistance in human lung cancer cells through upregulation of aldo-keto reductase 1B10 and proteasome.
Free Radic. Res. 48(11) , 1371-85, (2014) In this study, we show that exposure of human lung cancer A549 cells to cisplatin (cis-diamminedichloroplatinum, CDDP) promotes production of nitric oxide (NO) through generation of reactive oxygen species (ROS) and resulting upregulation of inducible NO synt... |
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A surface on the androgen receptor that allosterically regulates coactivator binding.
Proc. Natl. Acad. Sci. U. S. A. 104 , 16074-9, (2007) Current approaches to inhibit nuclear receptor (NR) activity target the hormone binding pocket but face limitations. We have proposed that inhibitors, which bind to nuclear receptor surfaces that mediate assembly of the receptor's binding partners, might over... |
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Identification and characterization of mefloquine efficacy against JC virus in vitro.
Antimicrob. Agents Chemother. 53 , 1840-9, (2009) Progressive multifocal leukoencephalopathy (PML) is a rare but frequently fatal disease caused by the uncontrolled replication of JC virus (JCV), a polyomavirus, in the brains of some immunocompromised individuals. Currently, no effective antiviral treatment ... |
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Caffeine as an analgesic adjuvant for acute pain in adults.
Cochrane Database Syst. Rev. 12 , CD009281, (2014) This is an updated version of the original Cochrane review published in Issue 3, 2012. Caffeine has been added to common analgesics such as paracetamol, ibuprofen, and aspirin, in the belief that it enhances analgesic efficacy. Evidence to support this belief... |
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Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets.
Cancer Lett. 346(2) , 217-24, (2014) Non-steroidal anti-inflammatory drugs (NSAIDs) are used extensively for analgesic and antipyretic treatments. In addition, NSAIDs reduce the risk and mortality to several cancers. Their mechanisms in anti-tumorigenesis are not fully understood, but both cyclo... |
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Anti-leukemic response of a NSAID, tolfenamic acid.
Target. Oncol. 9(2) , 135-44, (2014) Tolfenamic acid (TA), a non-steroidal anti-inflammatory drug, is known to inhibit human cancer cells and mouse tumor growth in some cancer models; however, its anti-leukemic response has not been evaluated. TA targets specificity protein (Sp) transcription fa... |