Beta-boswellic acid
Beta-boswellic acid structure
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Common Name | Beta-boswellic acid | ||
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| CAS Number | 631-69-6 | Molecular Weight | 456.700 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 556.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C30H48O3 | Melting Point | 130-135ºC | |
| MSDS | Chinese USA | Flash Point | 304.1±26.6 °C | |
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Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.
Bioorg. Med. Chem. Lett. 22 , 431-5, (2012) Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines thereby leading to the development of a possible SAR. One ... |
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A comparative study of proapoptotic potential of cyano analogues of boswellic acid and 11-keto-boswellic acid.
Eur. J. Med. Chem. 46 , 1356-66, (2011) Semi-synthetic analogues of β-boswellic acid (BA) and 11-keto-β-boswellic acid (KBA) were comparatively evaluated for in vitro cytotoxicity against human myeloid leukaemia (HL-60) and human cervical carcinoma (HeLa) cells. 2-Cyano analogues of both the triter... |
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The "MESACA" study: methylsulfonylmethane and boswellic acids in the treatment of gonarthrosis.
Adv. Ther. 28(10) , 894-906, (2011) Osteoarthritis is a chronic rheumatoid disease mediated by metalloproteinases and inflammatory cytokines. Methylsulfonylmethane (MSM) and boswellic acids (BA) each show promise in the treatment of inflammatory processes, but the efficacy of combined treatment... |
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Synthesis and pharmacokinetic profile of rhein- boswellic acid conjugate
Bioorg. Med. Chem. Lett. 22(24) , 7582-7, (2012) A novel gastro-sparing prodrug of rhein and boswellic acid was designed for the management of osteoarthritis and its synthesis, characterization and pharmacokinetic profile is reported. The prodrug was activated by hydrolysis releasing rhein (91%) and boswell... |
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In vitro and in vivo inhibitory activities of four Indian medicinal plant extracts and their major components on rat aldose reductase and generation of advanced glycation endproducts.
Phytother Res. 27(5) , 753-60, (2013) The polyol enzyme aldose reductase (AR) and advanced glycation endproducts (AGEs) play an important role in diabetic complications such as cataracts. The purpose of this study was to investigate four standardized plant extracts used for the treatment of diabe... |
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Determination of major boswellic acids in plasma by high-pressure liquid chromatography/mass spectrometry.
J. Pharm. Biomed. Anal. 56(5) , 998-1005, (2011) Until now, dexamethasone is the medication of choice to reduce peritumoral edema associated with primary and secondary brain tumors. Because of the severe side effects accompanying such a treatment the interest in alternative agents that may be co-administere... |
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Complexation with phosphatidyl choline as a strategy for absorption enhancement of boswellic acid.
Drug Deliv. 17(8) , 587-95, (2010) Boswellic acids (BAs) are isolated from oleo gum resin of Boswellia serrata and are reported to be effective as anti-inflammatory, hypolipidemic, immunomodulatory, and anti-tumor. Pharmacokinetic studies of boswellic acid reveal its poor absorption through th... |
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Boswellic acid induces epigenetic alterations by modulating DNA methylation in colorectal cancer cells.
Cancer Biol. Ther. 13(7) , 542-52, (2012) Accumulating evidence suggests that chemopreventive effects of some dietary polyphenols may in part be mediated by their ability to influence epigenetic mechanisms in cancer cells. Boswellic acids, derived from the plant Boswellia serrata, have long been used... |
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Boswellic acid inhibits inflammatory angiogenesis in a murine sponge model
Microvasc. Res. 82(3) , 263-8, (2011) The aim of the present study was to investigate the effects of boswellic acid (BA) on key components of inflammatory angiogenesis in the murine cannulated sponge implant angiogenesis model. Polyester–polyurethane sponges, used as a framework for fibrovascular... |
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An in vitro study of the role of β-boswellic acid in the microtubule assembly dynamics
FEBS Lett. 586(23) , 4132-8, (2012) Highlights ► The gum resin of plants boswellia has long been used in Oriental Medicine to prevent amnesia. ► β-boswellic acid (BBA) is the major component of the gum. ► We investigated the role of BBA in tubulin assembly dynamics by spectrophotometric and ele... |