FEBS Letters 2012-11-30

An in vitro study of the role of β-boswellic acid in the microtubule assembly dynamics

Oveis Karima, Gholamhossein Riazi, Sirus Khodadadi, Reza Yousefi, Karim Mahnam, Farzad Mokhtari, Tayebe Cheraghi, Elham Hoveizi, Ali Akbar Moosavi-Movahedi

Index: FEBS Lett. 586(23) , 4132-8, (2012)

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Abstract

Highlights ► The gum resin of plants boswellia has long been used in Oriental Medicine to prevent amnesia. ► β-boswellic acid (BBA) is the major component of the gum. ► We investigated the role of BBA in tubulin assembly dynamics by spectrophotometric and electron microscopic methods. ► Binding number and constant of BBA with tubulin was elucidated from titration curves. ► A binding site and association energy was suggested by the mean of molecular dynamic simulation.