Bioorganic & Medicinal Chemistry Letters 2012-01-01

Acyl derivatives of boswellic acids as inhibitors of NF-κB and STATs.

Ajay Kumar, Bhahwal A Shah, Samar Singh, Abid Hamid, Shashank K Singh, Vijay K Sethi, Ajit K Saxena, Jaswant Singh, Subhash C Taneja

Index: Bioorg. Med. Chem. Lett. 22 , 431-5, (2012)

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Abstract

Boswellic acid acylates including their epimers were synthesized and screened against a panel of human cancer cell lines. They exhibited a range of cytotoxicity against various human cancer cell lines thereby leading to the development of a possible SAR. One of the identified lead compounds was found to be an inhibitor of the NF-κB and STAT proteins, warranting further investigations to be developed into a potential anticancer lead.Copyright © 2011 Elsevier Ltd. All rights reserved.