Emodin
Emodin structure
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Common Name | Emodin | ||
|---|---|---|---|---|
| CAS Number | 518-82-1 | Molecular Weight | 270.237 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 586.9±39.0 °C at 760 mmHg | |
| Molecular Formula | C15H10O5 | Melting Point | 255 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 322.8±23.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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The direct anti-MRSA effect of emodin via damaging cell membrane.
Appl. Microbiol. Biotechnol. 99 , 7699-709, (2015) Methicillin-resistant Staphylococcus aureus (MRSA) has become an important bacterium for nosocomial infection. Only a few antibiotics can be effective against MRSA. Therefore, searching for new drugs against MRSA is important. Herein, anti-MRSA activities of ... |
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Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.
Chin. J. Integr. Med. 18(9) , 708-13, (2012) To investigate the effect of prescription compatibility on the pharmacokinetics of components from Dachengqi Decoction (DCQD, ) in rats.Twenty-four male rats were randomly and equally divided into the DCQD group, Dahuang (Radix et Rhizoma Rhei, Polygonaceae) ... |
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Isotonic sodium bicarbonate-triggered emodin release from borate stabilized emodin nanoparticles-loaded polymeric microgel films.
Int. J. Pharm. 469(1) , 80-7, (2014) Hydrosoluble emodin-borate (EmB) nanoparticles (NPs) were fabricated by a simple solvent exchange method to address emodin's poor water solubility. As the result, negative charges were introduced in the surface of EmB NPs. In addition, layer-by-layer assemble... |
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Effects of a Tricaprylin Emulsion on Anti-glomerular Basement Membrane Glomerulonephritis in Rats: In Vivo and in Silico Studies.
Biol. Pharm. Bull. 38 , 1175-84, (2015) Glomerulonephritis (GN) is a set of pathological conditions that result in the destruction of glomeruli and loss of renal function, commonly leading to the development of end-stage renal disease. Current pharmacotherapy is limited to immunosuppressive therapy... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta.
Br. J. Pharmacol. 171(18) , 4300-10, (2014) Dysregulated tonic tension and calcium sensitization in blood vessels has frequently been observed in many cardiovascular diseases. Despite a huge therapeutic potential, little is known about natural products targeting tonic tension and calcium sensitization.... |
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Modification of emodin and aloe-emodin by glycosylation in engineered Escherihia coli.
World J. Microbiol. Biotechnol. 31(4) , 611-9, (2015) Glycosyltransferase from Bacillus licheniformis DSM13 (YjiC) was used for enzymatic modification of emodin and aloe-emodin in vitro and in vivo. In order to increase the availability of UDP-glucose, three genes involved in the production of precursors of NDP-... |
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Emodin suppresses maintenance of stemness by augmenting proteosomal degradation of epidermal growth factor receptor/epidermal growth factor receptor variant III in glioma stem cells.
Stem Cells Dev. 24(3) , 284-95, (2015) There is a growing body of evidence that small subpopulations of cells with stem cell-like characteristics within most solid tumors are responsible for the malignancy of aggressive cancer cells and that targeting these cells might be a good therapeutic strate... |
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Determination of the Mycotoxin Content in Distiller's Dried Grain with Solubles Using a Multianalyte UHPLC-MS/MS Method.
J. Agric. Food Chem. 63 , 9441-51, (2015) There are more than 300 potential mycotoxins that can contaminate food and feed and cause adverse effects in humans and animals. The data on the co-occurrence of mycotoxins in novel animal feed materials, such as distiller's dried grain with solubles (DDGS), ... |