International Journal of Pharmaceutics 2014-07-20

Isotonic sodium bicarbonate-triggered emodin release from borate stabilized emodin nanoparticles-loaded polymeric microgel films.

Lin Wang, Xiaohan Wang, Xiaozhou Li

Index: Int. J. Pharm. 469(1) , 80-7, (2014)

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Abstract

Hydrosoluble emodin-borate (EmB) nanoparticles (NPs) were fabricated by a simple solvent exchange method to address emodin's poor water solubility. As the result, negative charges were introduced in the surface of EmB NPs. In addition, layer-by-layer assembled multilayer films containing cation-rich polymeric microgels (named PAHD) and sodium carboxymethyl cellulose (NaCMC) were employed as drug carrier. Anionic EmB can be loaded into the PAHD/CMC multilayer films. The influences of various experimental parameters on cargo capacity of the PAHD/CMC film were studied in detail. The loaded EmB can be released in the form of emodin molecule in presence of isotonic sodium bicarbonate (ISB) solution. Gratifyingly, EmB did not almost release in presence of water, PBS buffer solution, 0.9% normal saline, and 5% glucose solution.Copyright © 2014 Elsevier B.V. All rights reserved.