Harpagoside
Harpagoside structure
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Common Name | Harpagoside | ||
|---|---|---|---|---|
| CAS Number | 19210-12-9 | Molecular Weight | 494.488 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 720.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C24H30O11 | Melting Point | 120ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 244.3±26.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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What the devil is in your phytomedicine? Exploring species substitution in Harpagophytum through chemometric modeling of 1H-NMR and UHPLC-MS datasets.
Phytochemistry 106 , 104-15, (2014) Harpagophytum procumbens (Pedaliaceae) and its close taxonomical ally Harpagophytum zeyheri, indigenous to southern Africa, are being harvested for exportation to Europe where phytomedicines are developed to treat inflammation-related disorders. The phytochem... |
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Metabolic differentiations and classification of Verbascum species by NMR-based metabolomics.
Phytochemistry 72(16) , 2045-51, (2011) The genus Verbascum L. (mulleins) comprises of about 360 species of flowering plants in the Scrophulariaceae family. Mulleins have been used in the traditional folk medicine for centuries, for treatment of a wide range of human ailments, inter alia bronchitis... |
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[Simultaneous determination of five constituents in Scrophularia ningpoensis by HPLC].
Zhongguo Zhong Yao Za Zhi 36(6) , 709-11, (2011) To develop an HPLC method for the simultaneous quantitation of five constituents in Scrophularia ningpoensis.Samples were analyzed on an Agilent SB-C18 column(4.6 mm x 250 mm, 5 microm) eluted with acetonitrile and water containing 0.03% phosphate acid as mob... |
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Effect of nanoconfinement on polymer dynamics: surface layers and interphases.
PLoS ONE 9(7) , e103118, (2014) We present neutron spin echo experiments that address the much debated topic of dynamic phenomena in polymer melts that are induced by interacting with a confining surface. We find an anchored surface layer that internally is highly mobile and not glassy as h... |
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Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro.
Bioorg. Med. Chem. 19 , 4882-6, (2011) Harpagide (1) and harpagoside (2) are two iridoid glycosides existing in many medicinal plants. Although they are believed to be the main bioactive compounds related to the anti-inflammatory efficacy of these plants, the mechanisms of their anti-inflammatory ... |
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Preparative isolation and purification of harpagoside from Scrophularia ningpoensis hemsley by high-speed counter-current chromatography.
Phytochem. Anal. 17(6) , 406-8, (2006) The bioactive component harpagoside was successfully separated from the crude extract of Scrophularia ningpoensis Hemsley by one-step purification using high-speed counter-current chromatography (HSCCC). A two-phase solvent system containing n-butanol:ethyl a... |
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Antiinflammatory activities of Hungarian Stachys species and their iridoids.
Phytother Res. 26(4) , 505-9, (2012) The antiinflammatory activities of aqueous extracts prepared from the aerial parts of ten Hungarian Stachys species were investigated in vivo in the carrageenan-induced paw oedema test after intraperitoneal and oral administration to rats. Some of the extract... |
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Optimization of solid-phase extraction for the liquid chromatography-mass spectrometry analysis of harpagoside, 8-para-coumaroyl harpagide, and harpagide in equine plasma and urine.
J. Chromatogr. Sci. 46(2) , 174-83, (2008) Solid-phase extraction cartridges among those usually used for screening in horse doping analyses are tested to optimize the extraction of harpagoside (HS), harpagide (HG), and 8-para-coumaroyl harpagide (8PCHG) from plasma and urine. Extracts are analyzed by... |
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Preparative isolation and purification of harpagoside and angroside C from the root of Scrophularia ningpoensis Hemsley by high-speed counter-current chromatography.
J. Sep. Sci. 35(19) , 2659-64, (2012) In this study, the bioactive component harpagoside and angroside C in the root of Scrophularia ningpoensis Hemsley was simultaneously separated by high-speed counter-current chromatography (HSCCC). A two-phase solvent system containing chloroform/n-butanol/me... |
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Harpagoside attenuates MPTP/MPP⁺ induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor.
J. Neurochem. 120(6) , 1072-83, (2012) Parkinson's disease is a chronic neurodegenerative movement disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. New therapeutic approaches aiming at delaying or reversing the neurodegenerative process are under ac... |