L-penicillamine
L-penicillamine structure
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Common Name | L-penicillamine | ||
|---|---|---|---|---|
| CAS Number | 1113-41-3 | Molecular Weight | 149.211 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 251.8±35.0 °C at 760 mmHg | |
| Molecular Formula | C5H11NO2S | Melting Point | 206ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 106.1±25.9 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Circular muscle contraction in the mice rectum plays a key role in morphine-induced constipation.
Neurogastroenterol. Motil. 26(10) , 1396-407, (2014) Although opioids induce intestinal muscle contraction and provoke constipation, the intestinal region(s) that contribute to the constipation have remained unclear. We report here a region-specific response of intestinal muscle contraction to morphine and its ... |
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Inhibitors of bacterialN-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity
Bioorg. Med. Chem. Lett. 19 , 6350-2, (2009) A screen biased toward compounds containing zinc-binding groups (ZBG’s) delivered a number of micromolar inhibitors of DapE from Haemophilus influenzae, including l-captopril (IC 50 = 3.3 μM, K i = 1.8 μM). In vitro antimicrobial activity was demonstrated for... |
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Acetyl- and butyryl-cholinesterase inhibitory activities of the edible brown alga Eisenia bicyclis.
Arch. Pharm. Res. 38 , 1477-87, (2015) As part of our ongoing isolation of cholinesterase (ChE) inhibitors from natural marine sources, the bioactivity of the ethanolic extracts from 12 Korean seaweeds were screened for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholin... |
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BACE1 and cholinesterase inhibitory activities of Nelumbo nucifera embryos.
Arch. Pharm. Res. 38 , 1178-87, (2015) The aim of the present study was to evaluate the comparative anti-Alzheimer's disease (AD) activities of different parts of Nelumbo nucifera (leaves, de-embryo seeds, embryos, rhizomes, and stamens) in order to determine the selectivity and efficient use of i... |
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The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer's disease, anti-diabetic, and anti-inflammatory activities.
Arch. Pharm. Res. 37(10) , 1354-63, (2014) To investigate the effect of C-glycosylation at different positions of luteolin, the structure-activity relationships of luteolin and a pair of isomeric C-glycosylated derivatives orientin and isoorientin, were evaluated. We investigated the effects of C-glyc... |
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Covalent bonding of homochiral metal-organic framework in capillaries for stereoisomer separation by capillary electrochromatography.
Electrophoresis 37 , 601-8, (2016) In this work, a [Cu(mal)(bpy)]⋅H2O (mal, L-(-)-malic acid; bpy, 4,4'-bipyridyl) homochiral metal-organic frameworks (MOFs) was synthesized and used for modifying the inner walls of capillary columns by utilizing amido bonds to form covalent links between the ... |
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A Comprehensive Analysis of Selenium-Binding Proteins in the Brain Using Its Reactive Metabolite.
Chem. Pharm. Bull. 64 , 52-8, (2016) The intracellular metabolism of selenium in the brain currently remains unknown, although the antioxidant activity of this element is widely acknowledged to be important in maintaining brain functions. In this study, a comprehensive method for identifying the... |
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Antioxidant, analgesic and anti-inflammatory activities of the methanolic extract of Piper betle leaves.
Avicenna J Phytomed 3 , 112-25, (2014) The present study was designed to evaluate the antioxidant, analgesic, and anti-inflammatory activities of the methanolic extract of Piper betle leaves (MPBL).MPBL was evaluated for anti-inflammatory activity using carrageenan-induced hind paw edema model. An... |
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Molecular hydrogen protects chondrocytes from oxidative stress and indirectly alters gene expressions through reducing peroxynitrite derived from nitric oxide.
Med Gas Res 1 , 18, (2011) Molecular hydrogen (H2) functions as an extensive protector against oxidative stress, inflammation and allergic reaction in various biological models and clinical tests; however, its essential mechanisms remain unknown. H2 directly reacts with the strong reac... |
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Elevated incidence of polyp formation in APC(Min/⁺)Msh2⁻/⁻ mice is independent of nitric oxide-induced DNA mutations.
PLoS ONE 8 , e65204, (2013) Gut microbiota has been linked to a number of human diseases including colon cancer. However, the mechanism through which gut bacteria influence colon cancer development and progression remains unclear. Perturbation of the homeostasis between the host immune ... |