Bioorganic & Medicinal Chemistry Letters 2009-01-01

Inhibitors of bacterialN-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity

Danuta Gillner, Nicola Armoush, Richard C. Holz, Daniel P. Becker, Danuta Gillner, Nicola Armoush, Richard C. Holz, Daniel P. Becker

Index: Bioorg. Med. Chem. Lett. 19 , 6350-2, (2009)

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Abstract

A screen biased toward compounds containing zinc-binding groups (ZBG’s) delivered a number of micromolar inhibitors of DapE from Haemophilus influenzae, including l-captopril (IC 50 = 3.3 μM, K i = 1.8 μM). In vitro antimicrobial activity was demonstrated for l-captopril against Escherichia coli.