Cyclosporin A
Cyclosporin A structure
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Common Name | Cyclosporin A | ||
|---|---|---|---|---|
| CAS Number | 59865-13-3 | Molecular Weight | 1202.611 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 1293.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C62H111N11O12 | Melting Point | 148-151°C | |
| MSDS | Chinese USA | Flash Point | 736.3±34.3 °C | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Proteomic analysis in serum of rat hind-limb allograft tolerance induced by immunosuppressive therapy with adipose-derived stem cells.
Plast. Reconstr. Surg. 134(6) , 1213-23, (2014) Adipose-derived stem cells combined with transient immunosuppression prolonged vascularized composite tissue allotransplant survival and induced immune tolerance in a rodent hind-limb model. The authors investigated serum proteins in the adipose-derived stem ... |
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Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents.
Am. J. Physiol. Cell Physiol. 307(5) , C479-92, (2014) It has been difficult to separate/identify the roles of ClC-2 and CFTR in Cl(-) transport studies. Using pharmacological agents, we aimed to differentiate functionally between ClC-2 and CFTR Cl(-) channel currents. Effects of CFTR inhibitor 172 (CFTRinh172), ... |
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The Ca²⁺-calmodulin-Ca²⁺/calmodulin-dependent protein kinase II signaling pathway is involved in oxidative stress-induced mitochondrial permeability transition and apoptosis in isolated rat hepatocytes.
Arch. Toxicol. 88(9) , 1695-709, (2014) Oxidative stress (OS) is a common event in most hepatopathies, leading to mitochondrial permeability transition pore (MPTP) formation and further exacerbation of both OS from mitochondrial origin and cell death. Intracellular Ca²⁺ increase plays a permissive ... |
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Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.
PLoS ONE 9(11) , e112413, (2014) Parkinson disease (PD) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called Lewy bodies. Genetic predisposition, such as point mutations and copy number v... |
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Toxicity of copper on isolated liver mitochondria: impairment at complexes I, II, and IV leads to increased ROS production.
Cell Biochem. Biophys. 70(1) , 367-81, (2014) Oxidative damage has been implicated in disorders associated with abnormal copper metabolism and also Cu(2+) overloading states. Besides, mitochondria are one of the most important targets for Cu(2+), an essential redox transition metal, induced hepatotoxicit... |
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Elemol from Chamaecyparis obtusa ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis.
Int. J. Mol. Med. 36 , 463-72, (2015) Chamaecyparis obtusa has been traditionally used as an antibiotic agent and in cosmetics for the prevention of microorganism infection and skin troubles. Atopic dermatitis (AD) is a chronic inflammatory skin disease that encompasses immunologic responses, sus... |
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Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.
Hum. Mol. Genet. 24(1) , 86-99, (2014) Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by polyglutamine expansions in the amino-terminal region of the huntingtin (Htt) protein. At the cellular level, neuronal death is accompanied by the proteolytic cleavage, mi... |
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Resistance to daunorubicin, imatinib, or nilotinib depends on expression levels of ABCB1 and ABCG2 in human leukemia cells.
Chem. Biol. Interact. 219 , 203-10, (2014) The effect of ABCB1 (P-gp, (P-glycoprotein), MDR1) and ABCG2 (BCRP1, (breast cancer resistance protein 1)) expressions on cell resistance to daunorubicin (DRN), imatinib, and nilotinib was studied in human leukemia cells. We used a set of cells derived from a... |
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Calcium mobilization is both required and sufficient for initiating chromatin decondensation during activation of peripheral T-cells.
Mol. Immunol. 63(2) , 540-9, (2015) Antigen engagement of the T-cell receptor (TCR) induces a rapid and dramatic decondensation of chromatin that is necessary for T-cell activation. This decondensation makes T-cells competent to respond to interleukin-2 providing a mechanism to ensure clonotypi... |
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NFATc1 activity regulates the expression of myocilin induced by dexamethasone.
Exp. Eye Res. 130 , 9-16, (2015) Mutations in the myocilin gene (MYOC) account for 10% of juvenile open-angle glaucoma cases and 3-4% of adult onset primary open-angle glaucoma cases. It is a secreted glycoprotein found in many ocular and non-ocular tissues and has been linked to elevated in... |