7-Hydroxy-4-(trifluoromethyl)coumarin
7-Hydroxy-4-(trifluoromethyl)coumarin structure
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Common Name | 7-Hydroxy-4-(trifluoromethyl)coumarin | ||
|---|---|---|---|---|
| CAS Number | 575-03-1 | Molecular Weight | 230.140 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 311.4±42.0 °C at 760 mmHg | |
| Molecular Formula | C10H5F3O3 | Melting Point | 178-180 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 142.2±27.9 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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HepG2 cells as an in vitro model for evaluation of cytochrome P450 induction by xenobiotics.
Arch. Pharm. Res. 38 , 691-704, (2015) Although various in vitro assays have been developed to evaluate the cytochrome P450 (CYP)-inducing potential of drug candidates, there is a continuing need for the development of a reliable model in drug discovery. The objective of the present study was to c... |
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BFCOD activity in fish cell lines and zebrafish embryos and its modulation by chemical ligands of human aryl hydrocarbon and nuclear receptors.
Environ. Sci. Pollut. Res. Int. 22 , 16393-404, (2015) Assessment of exposure and effect of fish to pharmaceuticals that contaminate aquatic environment is a current major issue in ecotoxicology and there is a need to develop specific biological marker to achieve this goal. Benzyloxy-4-trifluoromethylcoumarin-O-d... |
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Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2.
Toxicol. Appl. Pharmacol. 289 , 223-30, (2015) Combustion processes generate different types of particulate matter (PM) that can have deleterious effects on the pulmonary and cardiovascular systems. Environmentally persistent free radicals (EPFRs) represent a type of particulate matter that is generated a... |
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Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter.
Biochem. Pharmacol. 95 , 126-32, (2015) Combustion processes generate particulate matter (PM) that can affect human health. The presence of redox-active metals and aromatic hydrocarbons in the post-combustion regions results in the formation of air-stable, environmentally persistent free radicals (... |
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Pharmacokinetics and metabolism of AMG 232, a novel orally bioavailable inhibitor of the MDM2-p53 interaction, in rats, dogs and monkeys: in vitro-in vivo correlation.
Xenobiotica 45 , 681-92, (2015) 1. AMG 232 is a novel inhibitor of the p53-MDM2 protein-protein interaction currently in Phase I clinical trials for multiple tumor indications. The objectives of the investigations reported in this article were to characterize the pharmacokinetic and drug me... |
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Design, synthesis, and evaluation of coumarin-based molecular probes for imaging of myelination.
J. Med. Chem. 54 , 2331-40, (2011) Myelination represents one of the most fundamental biological processes in the vertebrate nervous system. Abnormalities and changes in myelination in the central nervous system (CNS) are seen in many neurodegenerative disorders, such as multiple sclerosis (MS... |
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Coumarins as novel 17beta-hydroxysteroid dehydrogenase type 3 inhibitors for potential treatment of prostate cancer.
Bioorg. Med. Chem. Lett. 20 , 272-5, (2010) The synthesis and SAR studies of 3- and 4-substituted 7-hydroxycoumarins as novel 17beta-HSD3 inhibitors are discussed. The most potent compounds from this series exhibited low nanomolar inhibitory activity with acceptable selectivity versus other 17beta-HSD ... |
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Effects of plant-derived phenols on rat liver cytochrome P450 2B1 activity.
Anticancer Res. 22(3) , 1699-703, (2002) Dietary constituents contain a variety of compounds that are known to modulate liver enzyme activity. In this report, the plant-derived phenols catechin, chlorogenic acid, diosmin, epigallo-catechin gallate (EGCG), naringenin, quercetin and resveratrol were s... |
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Influence of diet supplementation with green tea extract on drug-metabolizing enzymes in a mouse model of monosodium glutamate-induced obesity.
Eur. J. Nutr. , (2015) Consumption of dietary supplements with green tea extract (GTE) is popular for weight management, but it may be accompanied by various side effects, including interactions with drugs. The aim of the present in vivo study was to evaluate the effect of defined ... |
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Identification of UGT2B9*2 and UGT2B33 isolated from female rhesus monkey liver.
Arch. Biochem. Biophys. 426(1) , 55-62, (2004) Two UDP-glucuronosyltransferases (UGT2B9(*)2 and UGT2B33) have been isolated from female rhesus monkey liver. Microsomal preparations of the cell lines expressing the UGTs catalyzed the glucuronidation of the general substrate 7-hydroxy-4-(trifluoromethyl)cou... |