2,4-Diamino-6-hydroxypyrimidine
2,4-Diamino-6-hydroxypyrimidine structure
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Common Name | 2,4-Diamino-6-hydroxypyrimidine | ||
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| CAS Number | 56-06-4 | Molecular Weight | 126.12 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 524.0±53.0 °C at 760 mmHg | |
| Molecular Formula | C4H6N4O | Melting Point | 285-286 °C (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 270.7±30.9 °C | |
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GTP cyclohydrolase I: purification, characterization, and effects of inhibition on nitric oxide synthase in nocardia species.
Appl. Environ. Microbiol. 69(12) , 7507-7513, (2003) GTP cyclohydrolase I (GTPCH) catalyzes the first step in pteridine biosynthesis in Nocardia sp. strain NRRL 5646. This enzyme is important in the biosynthesis of tetrahydrobiopterin (BH4), a reducing cofactor required for nitric oxide synthase (NOS) and other... |
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Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure.
Hypertension 52(3) , 484-90, (2008) GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in de novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial NO synthase (eNOS) dictating, at least partly, the balance of NO and superoxide produced by this enzyme. The aim... |
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Attenuation of biopterin synthesis prevents Escherichia coli K1 invasion of brain endothelial cells and the development of meningitis in newborn mice.
J. Infect. Dis. 207(1) , 61-71, (2013) Elevated levels of pterins and nitric oxide (NO) are observed in patients with septic shock and bacterial meningitis. We demonstrate that Escherichia coli K1 infection of human brain microvascular endothelial cells (HBMECs) induces the expression of guanosine... |
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A typical N-terminal extensions confer novel regulatory properties on GTP cyclohydrolase isoforms in Drosophila melanogaster.
J. Biol. Chem. 281(44) , 33302-12, (2006) The cofactor tetrahydrobiopterin plays critical roles in the modulation of the signaling molecules dopamine, serotonin, and nitric oxide. Deficits in cofactor synthesis have been associated with several human hereditary diseases. Responsibility for the regula... |
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Role of tetrahydrobiopterin in resistance to myocardial ischemia in Brown Norway and Dahl S rats.
Am. J. Physiol. Heart Circ. Physiol. 297(5) , H1783-91, (2009) Previously we showed that Brown Norway (BN/Mcw) rats are more resistant to myocardial ischemia-reperfusion (I/R) injury than Dahl S (SS/Mcw) rats due to increased nitric oxide (x NO) generation secondary to increased heat shock protein 90 (HSP90) association ... |
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Role of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts.
J. Cardiovasc. Surg. (Torino.) 44(1) , 37-49, (2003) It has recently been shown that nitric oxide synthase in the presence of suboptimal levels of tetrahydrobiopterin (BH(4)), an essential cofactor of nitric oxide synthase, may favor increased production of oxygen free radicals. This study was designed to defin... |
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Increased vulnerability to ischemia/reperfusion-induced ventricular tachyarrhythmias by pre-ischemic inhibition of nitric oxide synthase in isolated rat hearts
Cardiovasc. Pathol. 12(1) , 49-56, (2003) Introduction: The relationship between vulnerability to reperfusion-induced ventricular tachyarrhythmias, such as ventricular tachycardia (VT) and fibrillation (VF), and the endogenous activity of nitric oxide synthase (NOS) has not been well documented. The ... |
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Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats.
Crit. Care Med. 30(11) , 2520-7, (2002) Guanosine triphosphate-cyclohydrolase I (GTP-CHI) is the first and rate-limiting enzyme for the de novo biosynthesis of biopterin. The objective of present study was to observe the effect of 2,4-diamino-6-hydroxy-pyrimidine (DAHP), an inhibitor of GTP-CHI, on... |
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2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner.
Biochim. Biophys. Acta 1780(7-8) , 960-5, (2008) 2,4-Diamino-6-hydroxypyrimidine (DAHP) is considered a specific inhibitor of BH(4) biosynthesis and is widely used in order to elucidate the possible biological function of BH(4) in various cells. In the present study, we found that both the synthesis of tetr... |
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Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats.
J. Pharmacol. Sci. 107(1) , 49-56, (2008) Tetrahydrobiopterin (BH4) deficiency has been suggested to be an important factor in vascular endothelial dysfunction. In this study, we investigated the influence of decreased BH4 level produced by administration of 2,4-diamino-6-hydroxypyrimidine (DAHP), a ... |