2,4-Diamino-6-hydroxypyrimidine structure
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Common Name | 2,4-Diamino-6-hydroxypyrimidine | ||
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CAS Number | 56-06-4 | Molecular Weight | 126.12 | |
Density | 1.6±0.1 g/cm3 | Boiling Point | 524.0±53.0 °C at 760 mmHg | |
Molecular Formula | C4H6N4O | Melting Point | 285-286 °C (dec.)(lit.) | |
MSDS | Chinese USA | Flash Point | 270.7±30.9 °C |
Use of 2,4-Diamino-6-hydroxypyrimidine2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1]. |
Name | 2,4-Diamino-6-hydroxypyrimidine |
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Synonym | More Synonyms |
Description | 2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1]. |
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Related Catalog | |
Target |
GTP cyclohydrolase I[1] |
References |
Density | 1.6±0.1 g/cm3 |
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Boiling Point | 524.0±53.0 °C at 760 mmHg |
Melting Point | 285-286 °C (dec.)(lit.) |
Molecular Formula | C4H6N4O |
Molecular Weight | 126.12 |
Flash Point | 270.7±30.9 °C |
Exact Mass | 126.054161 |
PSA | 98.05000 |
LogP | -1.29 |
Vapour Pressure | 0.0±1.4 mmHg at 25°C |
Index of Refraction | 1.770 |
Storage condition | Desiccate at +4°C |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi |
Risk Phrases | R36/37/38 |
Safety Phrases | S22-S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 29335995 |
~% 2,4-Diamino-6-h... CAS#:56-06-4 |
Literature: Popova; Studentsov Russian Journal of General Chemistry, 1997 , vol. 67, # 3 p. 435 - 438 |
~% 2,4-Diamino-6-h... CAS#:56-06-4 |
Literature: Terashima, Isamu; Kohda, Kohfuku Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 503 - 508 |
Precursor 3 | |
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DownStream 10 | |
HS Code | 2933599090 |
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Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
GTP cyclohydrolase I: purification, characterization, and effects of inhibition on nitric oxide synthase in nocardia species.
Appl. Environ. Microbiol. 69(12) , 7507-7513, (2003) GTP cyclohydrolase I (GTPCH) catalyzes the first step in pteridine biosynthesis in Nocardia sp. strain NRRL 5646. This enzyme is important in the biosynthesis of tetrahydrobiopterin (BH4), a reducing ... |
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Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure.
Hypertension 52(3) , 484-90, (2008) GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in de novo synthesis of tetrahydrobiopterin (BH4), an essential cofactor for endothelial NO synthase (eNOS) dictating, at least partly, the ba... |
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Attenuation of biopterin synthesis prevents Escherichia coli K1 invasion of brain endothelial cells and the development of meningitis in newborn mice.
J. Infect. Dis. 207(1) , 61-71, (2013) Elevated levels of pterins and nitric oxide (NO) are observed in patients with septic shock and bacterial meningitis. We demonstrate that Escherichia coli K1 infection of human brain microvascular end... |
2,6-diaminopyrimidin-4(3H)-one |
2,6-Diaminopyrimidin-4-one |
2,4-Diamino-6-hydroxypyrimidine |
2,6-diaminopyrimidin-4-ol |
4-Pyrimidinol, 2,6-diamino- |
2,4-Diamino-6-hydroxy |
2,6-diamino-4-hydroxy-pyrimidine |
6-hydroxy-2,4-diaminopyrimidine |
2,6-Diamino-4(1H)-pyrimidinone |
AURORA KA-376 |
MFCD00006098 |
2,4-Diamino-6-pyrimidinone |
2,6-Diaminopyrimidin-4(1H)-one |
EINECS 200-254-4 |
2,4-diaminohypoxanthine |
6-Aminoisocytosine |
6-Hydroxy-2,4-pyrimidinediamine |
DAHP |
2,4-DIAMINO-6-HYDROXY PYRIMIDINE |