56-06-4

56-06-4 structure

Name: 2,4-Diamino-6-hydroxypyrimidine
Chemical Name: 2,4-Diamino-6-hydroxypyrimidine
CAS Number: 56-06-4
Molecular Formula: C₄H₆N₄O
Molecular Weight: 126.12
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyrimidine compound Hydroxypyrimidine
Create Date: 2018-05-29 08:00:00
Modify Date: 2025-08-21 10:28:56
2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1].

Name	2,4-Diamino-6-hydroxypyrimidine
Synonyms	2,6-diaminopyrimidin-4(3H)-one 2,6-Diaminopyrimidin-4-one 2,4-Diamino-6-hydroxypyrimidine 2,6-diaminopyrimidin-4-ol 4-Pyrimidinol, 2,6-diamino- 2,4-Diamino-6-hydroxy 2,6-diamino-4-hydroxy-pyrimidine 6-hydroxy-2,4-diaminopyrimidine 2,6-Diamino-4(1H)-pyrimidinone AURORA KA-376 MFCD00006098 2,4-Diamino-6-pyrimidinone 2,6-Diaminopyrimidin-4(1H)-one EINECS 200-254-4 2,4-diaminohypoxanthine 6-Aminoisocytosine 6-Hydroxy-2,4-pyrimidinediamine DAHP 2,4-DIAMINO-6-HYDROXY PYRIMIDINE

Description	2,4-Diamino-6-hydroxypyrimidine is a specific GTP cyclohydrolase I inhibitor (the rate-limiting enzyme in de novo pterin synthesis), blocks BH4 synthesis and suppresses NO production[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	GTP cyclohydrolase I[1]
References	[1]. Sung YJ, et al. 2,4-Diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, suppresses nitric oxide production by chicken macrophages. Int J Immunopharmacol. 1994 Feb;16(2):101-8.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	29335995

696-83-3

56-06-4

Literature: Popova; Studentsov Russian Journal of General Chemistry, 1997 , vol. 67, # 3 p. 435 - 438

108-98-5

100061-59-4

831-91-4

56-06-4

Literature: Terashima, Isamu; Kohda, Kohfuku Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 503 - 508

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%