N,N'-Diacetyl-L-cystine
N,N'-Diacetyl-L-cystine structure
|
Common Name | N,N'-Diacetyl-L-cystine | ||
|---|---|---|---|---|
| CAS Number | 5545-17-5 | Molecular Weight | 324.374 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 715.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C10H16N2O6S2 | Melting Point | 55-72ºC | |
| MSDS | N/A | Flash Point | 386.5±32.9 °C | |
|
Influence of N,N'-diacetyl-L-cystine on D-galactosamine/lipopolysaccharide induced immunological liver failure in mice.
Yao Xue Xue Bao 39(10) , 782-6, (2004) To study the therapeutic effects of N,N'-diacetyl-L-cystine (DiNAC) on immunological liver failure.Serum ALT, AST and T cell subsets in peripheral blood of the experimental animals during the trial period were analyzed by an automatic serum analyzer and a flo... |
|
|
Immunomodulation with DiNAC-- a new approach to the treatment of atherosclerosis?
Expert Opin. Investig. Drugs 11(5) , 717-20, (2002) Not all antioxidants reduce atherosclerosis. This may be because atherosclerosis has an autoimmune, inflammatory pathogenesis. As probucol is both an antioxidant and an immunomodulatory drug, it may be the immunomodulatory effect that underlies its ability to... |
|
|
The new oral immunomodulating drug DiNAC induces brachial artery vasodilatation at rest and during hyperemia in hypercholesterolemic subjects, likely by a nitric oxide-dependent mechanism.
Atherosclerosis 196(1) , 275-82, (2008) To investigate if the immunomodulator drug DINAC (1) affects arterial dimensions in asymptomatic patients with hypercholesterolemia, (2) has effects on leucocyte markers of inflammation and (3) has in vitro effects on nitric oxide synthase (NOS) in human umbi... |
|
|
N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents.
J. Pharmacol. Exp. Ther. 288(3) , 1174-84, (1999) Oral N-acetyl-L-cysteine (NAC) is used clinically for treatment of chronic obstructive pulmonary disease. NAC is easily oxidized to its disulfide. We show here that N,N'-diacetyl-L-cystine (DiNAC) is a potent modulator of contact sensitivity (CS)/delayed type... |
|
|
Monitoring of the subtraction process in solid-phase representational difference analysis: characterization of a candidate drug.
Gene 271(2) , 183-92, (2001) In this study, we have applied and evaluated a modified cDNA representational difference analysis (RDA) protocol based on magnetic bead technology to study the molecular effects of a candidate drug (N,N'-diacetyl-L-cystine, DiNAC) in a model for atheroscleros... |
|
|
[Cysteine in parenteral nutrition: comparative study of N-acetyl-cysteine and N,N-diacetylcystine in the rat model].
Infusionstherapie 15(2) , 89-92, (1988) In this study the question of whether N-N-diacetylcystine (DAC), which is more stable than N-acetylcysteine (AcCYS), may provide a useful cysteine source for parenteral nutrition was investigated. In in vitro studies the release of cysteine from DAC was measu... |
|
|
The antiatherogenic effect of DiNAC: experimental findings supporting immunomodulation as a new treatment for atherosclerosis related diseases.
Cardiovasc. Drug Rev. 21(2) , 119-32, (2003) Inflammatory processes in the arterial wall are important in atherogenesis. The present review discusses the development of DiNAC as a potential new treatment modality for atherosclerosis related diseases. DiNAC, N,N'-diacetyl-L-cystine, is the disulphide dim... |
|
|
N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis.
J. Pharmacol. Exp. Ther. 299(1) , 76-82, (2001) Oxidation of lipoprotein-derived lipids is generally accepted to be important in atherogenesis, and lipophilic antioxidants have been suggested as potential antiatherosclerotic agents. The antiatherogenic effects observed by certain antioxidants, especially p... |
|
|
N,N-diacetyl-L-cystine improves endothelial function in atherosclerotic Watanabe heritable hyperlipidaemic rabbits.
Basic Clin Pharmacol Toxicol. 100(1) , 36-42, (2007) N,N-diacetyl-L-cystine (DiNAC), a novel immunomodulator, stimulates contact sensitivity/delayed type hypersensitivity reactions in mice induced by oxazolone and reduces atherosclerosis in Watanabe heritable hyperlipidaemic (WHHL) rabbits. Forty-week-old WHHL ... |