5545-17-5

5545-17-5 structure

Name: N,N'-Diacetyl-L-cystine
Chemical Name: (ac-cys-oh)2
CAS Number: 5545-17-5
Molecular Formula: C₁₀H₁₆N₂O₆S₂
Molecular Weight: 324.374
Catalog: Biochemical Amino acids and their derivatives Other amino acid derivatives
Create Date: 2018-06-20 05:53:28
Modify Date: 2024-01-03 02:34:17
N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits[1][2].

Name	(ac-cys-oh)2
Synonyms	N,N`-Diacetyl-L-cystine N,N'-Diacetyl-L-cystine N,N'-diacetyl-cystine N-acetyl-L-cystine ACETYL-L-CYSTINE DiNAC L-Cystine, N,N'-diacetyl- Cystine, N,N'-diacetyl-, L- diacetylcysteine L-Cystine,N,N'-diacetyl N,N''-Diacetyl-L-cysteine N-ACETYL CYSTINE

Description	N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
Target	Immunomodulator[1]
In Vivo	N,N'-Diacetyl-L-cystine (DiNAC; 0-973.11 μg/kg; oral administration; daily; for 12 weeks; WHHL rabbits) treatment reduces by 50% thoracic aorta atherosclerosis, without affecting plasma lipid levels[1]. Animal Model: Male heritable hyperlipidemic rabbit (WHHL) rabbits (10-22 weeks)[1] Dosage: 0 μg/kg, 9.73 μg/kg, or 973.11 μg/kg Administration: Oral administration; daily; for 12 weeks Result: Reduced by 50% thoracic aorta atherosclerosis, without affecting plasma lipid levels.
References	[1]. Wågberg M, et al. N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis. J Pharmacol Exp Ther. 2001 Oct;299(1):76-82. [2]. Särnstrand B, et al. N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. J Pharmacol Exp Ther. 1999 Mar;288(3):1174-84.

Density	1.5±0.1 g/cm3
Boiling Point	715.5±60.0 °C at 760 mmHg
Melting Point	55-72ºC
Molecular Formula	C₁₀H₁₆N₂O₆S₂
Molecular Weight	324.374
Flash Point	386.5±32.9 °C
Exact Mass	324.044983
PSA	183.40000
LogP	0.46
Vapour Pressure	0.0±5.0 mmHg at 25°C
Index of Refraction	1.583
Storage condition	-15°C
Stability	Moisture Sensitive