5545-17-5

• 常用中文名：N,N'-二乙酰基-L-胱氨酸
• 常用英文名：N,N'-Diacetyl-L-cystine
• CAS号：5545-17-5
• 分子式：C₁₀H₁₆N₂O₆S₂
• 分子量：324.374
• 相关类别： 生物化工 氨基酸及其衍生物 其他氨基酸衍生物
• 发布时间：2018-06-20 05:53:28
• 更新时间：2026-07-02 11:03:57
• N,N'-diacetyl-L-cystine (DiNAC) 是一种具有免疫调节特性的 N-乙酰基半胱氨酸的二硫二聚体。N,N'-diacetyl-L-cystine 是啮齿类动物中接触敏感/迟发型超敏反应的有效口服活性调节剂。N,N'-diacetyl-L-cystine 在高脂血症兔 (WHHL) 中也具有抗动脉粥样硬化的作用。

名称

• 中文名: N,N’-二乙酰-L-胱氨酸
• 英文名: (ac-cys-oh)2
• 中文别名: N-乙酰-L-半胱氨酸杂质38; N-乙酰半胱氨酸杂质C 标准品; N,N'-二乙酰胱氨酸; 乙酰半胱氨酸杂质C/A1A; (2R,2'R)-3,3'-二硫烷二基双(2-乙酰胺基丙酸); 乙酰半胱氨酸相关化合物C; 乙酰半胱氨酸杂质C 标准品; 乙酰半胱氨酸杂质10; 乙酰半胱氨酸杂质5(乙酰半胱氨酸杂质C); S - [2 - (乙酰氨基)乙基] 羧酸 ;N,N'-二乙酰-L-胱氨酸; N,N'-二乙酰-L-胱氨酸; 乙酰半胱氨酸杂质01; 双乙酰化-L-胱氨酸; 乙酰半胱氨酸杂质C
• 英文别名: Acetylcysteine Disulfide Dimer; N-acetyl-L-cystine; DiNAC; Acetylcysteine impurity C (A0152000)Q: What is Acetylcysteine impurity C (A0152000) Q: What is the CAS Number of Acetylcysteine impurity C (A0152000); Acetylcysteine Impurity 38; N,N-diacetylcystine; L-Cystine,N,N'-diacetyl; (AC-CYS-OH)2 //BP; N-ACETYL CYSTINE; (Ac-L-Cys-OH)2; N-ALPHA-ACETYL-L-CYSTINE; N,N'-diacetyl-cystine; ACETYL-L-CYSTINE; (2R)-3-{[(2R)-2-cboxy-2-acetamidoethyl]disulfanyl}-2-acetamidopropanoic acid; Acetylcysteine IMpurity C; (AC-CYS-OH)2; N,N'-Diacetyl-L-Cystine; L-Cystine, N,N'-diacetyl; Acetylcysteine Impurity 5（Acetylcysteine Impurity C）; N,N''-Diacetyl-L-cysteine; Acetylcysteine impurity C CRS; Acetyl Cysteine BP Impurity C; diacetylcysteine; (2R,2'R)-3,3'-disulfanediylbis(2-acetamidopropanoic acid); 3,3'-Dithiobis[(R)-2-acetylaminopropionic acid]; (Ac-L-Cys-OH)2(Disulfide bond) , Chiral purity); N,N`-Diacetyl-L-cystine; N,N’-Diacetyl-L-cystine; (Ac-Cys-OH)2 (Disulfide bond); S-(((R)-2-acetamido-2-cboxyethyl)thio)-N-acetylcysteine; N,N''-Diacetyl-L-cystine, 10 mM in DMSO; ACETYLCYSTEINE IMPURITY C / N,N`-DIACETYL- L-CYSTINE

物化性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 715.5±60.0 °C at 760 mmHg
• 熔点: 55-72ºC
• 分子式: C₁₀H₁₆N₂O₆S₂
• 分子量: 324.374
• 闪点: 386.5±32.9 °C
• 精确质量: 324.044983
• PSA: 183.40000
• LogP: 0.46
• 外观性状: 白色粉末
• 蒸汽压: 0.0±5.0 mmHg at 25°C
• 折射率: 1.583
• 储存条件: -15°C
• 稳定性: Moisture Sensitive

生物活性

• 描述: N,N'-diacetyl-L-cystine (DiNAC) 是一种具有免疫调节特性的 N-乙酰基半胱氨酸的二硫二聚体。N,N'-diacetyl-L-cystine 是啮齿类动物中接触敏感/迟发型超敏反应的有效口服活性调节剂。N,N'-diacetyl-L-cystine 在高脂血症兔 (WHHL) 中也具有抗动脉粥样硬化的作用。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 靶点:

  Immunomodulator[1]

• 体内研究: N,N'-二乙酰-L-胱氨酸(DiNAC；0-973.11μg/kg；口服给药；每日；12周；WHHL兔)治疗减少50%胸主动脉动脉粥样硬化,而不影响血浆脂质水平[1]。动物模型：雄性遗传性高脂血症兔(WHHL)兔(10-22周)[1]剂量：0μg/kg,9.73μg/kg或973.11μg/kg给药：口服给药；每日；12周结果：减少50%胸主动脉粥样硬化,不影响血浆脂质水平。
• 参考文献:

  [1]. Wågberg M, et al. N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis. J Pharmacol Exp Ther. 2001 Oct;299(1):76-82.

  [2]. Särnstrand B, et al. N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. J Pharmacol Exp Ther. 1999 Mar;288(3):1174-84.

安全

• 海关编码: 29225090

合成路线

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文献：Oba, Makoto; Tanaka, Kazuhito; Nishiyama, Kozaburo; Ando, Wataru Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 4173 - 4177

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