Fluoxetine Hydrochloride
Fluoxetine Hydrochloride structure
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Common Name | Fluoxetine Hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 59333-67-4 | Molecular Weight | 345.787 | |
| Density | 1.254g/cm3 | Boiling Point | 569.2ºC at 760 mmHg | |
| Molecular Formula | C17H19ClF3NO | Melting Point | 158.4-158.9ºC | |
| MSDS | N/A | Flash Point | 298ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial.
Phytother Res. 28(4) , 579-85, (2014) Curcumin, an active ingredient of Curcuma longa Linn (Zingiberaceae), has shown potential antidepressant-like activity in animal studies. The objectives of this trial were to compare the efficacy and safety of curcumin with fluoxetine in patients with major d... |
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Anti-depressant like activity of N-n-butyl-3-methoxyquinoxaline-2-carboxamide (6o) a 5-HT3 receptor antagonist.
Indian J. Exp. Biol. 51(6) , 435-43, (2013) The compound 6o (at 0.5, 1 and 2 mg/kg, ip) with optimum log P and pA2 value, was subjected to forced swim test (FST) and tail suspension test (TST). The compound 6o significantly reduced the duration of immobility in mice without affecting the base line loco... |
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K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science 347(6227) , 1256-9, (2015) TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the mechanisms that control channel gating are unclear. Here we present crystal structures of th... |
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Effects of active pharmaceutical ingredients mixtures in mussel Mytilus galloprovincialis.
Aquat. Toxicol. 153 , 12-26, (2014) Active pharmaceutical ingredients (APIs) are emergent environmental contaminants widely detected in surface waters as result of incomplete waste water treatment plant (WWTP) removal processes and improper disposal. The assessment of potential effects of APIs ... |
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α2-Adrenergic agonists including xylazine and dexmedetomidine inhibit norepinephrine transporter function in SK-N-SH cells.
Neurosci. Lett. 541 , 184-9, (2013) α2-Adrenergic agonists simulate norepinephrine (NE) action on α2 receptors of sympathetic neurons to mediate feedback inhibition of NE release. These agents are used as valuable adjuncts for management of hypertension and for anesthesia. Their action, equival... |
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Dose dependent effects of serotonergic agents on anxiety.
Acta Physiol. Hung. 101(4) , 479-87, (2014) The role of serotonin in depression and anxiety is still highly controversial. In this experiment the effect of two substances upon anxiety was studied in rats.Forty adult (45-55 weeks old) male Wistar rats were used to study the following behavioral paramete... |
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Rapamycin reverses pulmonary artery smooth muscle cell proliferation in pulmonary hypertension.
Am. J. Respir. Cell. Mol. Biol. 48(5) , 568-77, (2013) Pulmonary artery (PA) smooth muscle cell (SMC) proliferation in pulmonary hypertension (PH) may be linked to dysregulated mammalian target of rapamycin (mTOR) signaling. The mTOR pathway involves two independent complexes, mTORC1 and mTORC2, which phosphoryla... |
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[Antidepressant properties of beta-phenylglutamic acid hydrochloride (RGPU-135, glutarone) in comparison to imipramine, tianeptine, and fluoxetine].
Eksp. Klin. Farmakol. 76(3) , 7-9, (2013) The new glutamic acid derivative--beta-phenylglutamic acid hydrochloride (RGPU-135, glutarone) (in a dose of 26 mg/kg), imipramine (15 mg/kg), tianeptine (2.5 mg/kg) and fluoxetine (20 mg/kg), show antidepressant action in the tail suspension test and Porsolt... |
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A pooled analysis of six month comparative efficacy and tolerability in four randomized clinical trials: agomelatine versus escitalopram, fluoxetine, and sertraline.
CNS Spectr. 18(3) , 163-70, (2013) A pooled-analysis on the long-term outcome in four head-to-head studies: agomelatine versus fluoxetine, sertraline, and (twice) escitalopram. Method A meta-analytic approach was used. Hamilton Depression Rating Scale (HAM-D) scores, response and remission rat... |
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Chronic fluoxetine exposure alters movement and burrowing in adult freshwater mussels
Aquat. Toxicol. 151 , 27-35, (2014) • Fluoxetine induced disruption in movement and burrowing of freshwater mussels. • 67-d exposure and observation with exposure validation. • Comprehensive study of ecologically relevant endpoints. • Further evidence mollusks are exceptionally sensitive to SSR... |