Eksperimental'naia i klinicheskaia farmakologiia 2013-01-01

[Antidepressant properties of beta-phenylglutamic acid hydrochloride (RGPU-135, glutarone) in comparison to imipramine, tianeptine, and fluoxetine].

V V Bagmetova, Iu V Chernysheva, O V Merkushenkova, V M Berestovitskaia, I N Tiurenkov

Index: Eksp. Klin. Farmakol. 76(3) , 7-9, (2013)

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Abstract

The new glutamic acid derivative--beta-phenylglutamic acid hydrochloride (RGPU-135, glutarone) (in a dose of 26 mg/kg), imipramine (15 mg/kg), tianeptine (2.5 mg/kg) and fluoxetine (20 mg/kg), show antidepressant action in the tail suspension test and Porsolt swim test. All these drugs cause reduction in the intensity of depressive behavior and lead to increase in the rate of active behavior of avoidance of aversive situation with animals. The RGPU-135 compound shows antidepressant activity equal to that of imipramine, which is statistically significantly more pronounced than that of fluoxetine and tianeptine.