3,3'-Diethylthiacarbocyanine iodide
3,3'-Diethylthiacarbocyanine iodide structure
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Common Name | 3,3'-Diethylthiacarbocyanine iodide | ||
|---|---|---|---|---|
| CAS Number | 905-97-5 | Molecular Weight | 492.43900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H21IN2S2 | Melting Point | 268-270ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Structure-activity relationship of cyanine tau aggregation inhibitors.
J. Med. Chem. 52 , 3539-47, (2009) A structure-activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity depended on cyanine heterocycle, polymethine bridge length, and the nature of meso- and N-substituents.... |
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In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.
Proc. Natl. Acad. Sci. U. S. A. 105 , 9059-64, (2008) The growing resistance to current first-line antimalarial drugs represents a major health challenge. To facilitate the discovery of new antimalarials, we have implemented an efficient and robust high-throughput cell-based screen (1,536-well format) based on p... |
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Three-dimensional fluorescence lifetime tomography.
Med. Phys. 32(4) , 992-1000, (2005) Near-infrared fluorescence tomography using molecularly targeted lifetime-sensitive, fluorescent contrast agents have applications for early-stage cancer diagnostics. Yet, although the measurement of fluorescent lifetime imaging microscopy (FLIM) is extensive... |
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Genetic screening using the colour change of a PNA-DNA hybrid-binding cyanine dye.
Nucleic Acids Res. 30(2) , E3, (2002) As the relationship between human genes and various malfunctions and diseases becomes revealed at an ever-increasing pace, the need arises for the development of rapid genetic screening methods for diagnostic purposes. Genetic diseases show great diversity. S... |
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Leucine transport is affected by Bacillus thuringiensis Cry1 toxins in brush border membrane vesicles from Ostrinia nubilalis Hb (Lepidoptera: Pyralidae) and Sesamia nonagrioides Lefebvre (Lepidoptera: Noctuidae) midgut.
J. Membr. Biol. 214(3) , 157-64, (2006) The pore-forming activity of Cry1Ab, Cry1Fa and Cry1Ca toxins and their interaction with leucine transport mediated by the K(+)/leucine cotransporter were studied in brush border membrane vesicles (BBMVs) isolated from the midgut of Ostrinia nubilalis and Ses... |
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Photophysical properties of 3,3'-dialkylthiacarbocyanine dyes in organized media: unilamellar liposomes and thin polymer films.
Biochim. Biophys. Acta 1151 , 168, (1993) All symmetrical dialkylthiacarbocyanine dyes, with the exception of the diethyl derivatives, are incorporated into liposomes. Absorption and fluorescence data indicate a solubilization site close to the bilayer surface with the alkyl chains penetrating into t... |
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Molecular Rotors Provide Insights into Microscopic Structural Changes During Protein Aggregation.
J. Phys. Chem. B 119 , 10170-9, (2015) Changes in microscopic viscosity represent an important characteristic of structural transitions in soft matter systems. Here we demonstrate the use of molecular rotors to explore the changes in microrheology accompanying the transition of proteins from their... |
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The membrane potential has no detectable effect on the phosphocholine headgroup conformation in large unilamellar phosphatidylcholine vesicles as determined by 2H-NMR.
Biochim. Biophys. Acta 1153(2) , 257-61, (1993) In this study the effect of a transmembrane electrical potential on the phospholipid headgroup conformation was investigated using the 2H-NMR technique. Large unilamellar vesicles were prepared of dioleoylphosphatidylcholine, specifically 2H-labeled at the al... |
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Colorimetric detection of PNA-DNA hybridization using cyanine dyes.
Methods Mol. Biol. 208 , 131-42, (2002)
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Mix and measure fluorescence screening for selective quadruplex binders.
Nucleic Acids Res. 36 , e106, (2008) The human genome contains thousands of regions, including that of the telomere, that have the potential to form quadruplex structures. Many of these regions are potential targets for therapeutic intervention. There are many different folding patterns for quad... |