H-D-Abu-OH

H-D-Abu-OH Structure
H-D-Abu-OH structure
Common Name H-D-Abu-OH
CAS Number 2623-91-8 Molecular Weight 103.120
Density 1.1±0.1 g/cm3 Boiling Point 215.2±23.0 °C at 760 mmHg
Molecular Formula C4H9NO2 Melting Point 300ºC
MSDS Chinese USA Flash Point 83.9±22.6 °C

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

Anal. Chem. 81(10) , 3919-32, (2009)

We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass s...

Protein prosthesis: β-peptides as reverse-turn surrogates.

Protein Sci. 22(3) , 274-9, (2013)

The introduction of non-natural modules could provide unprecedented control over folding/unfolding behavior, conformational stability, and biological function of proteins. Success requires the interrogation of candidate modules in natural contexts. Here, expr...

Correlation between symmetry breaker position and the preferences of conformationally constrained homopeptides: a molecular dynamics investigation.

Biopolymers 90(5) , 695-706, (2008)

The conformational tendencies of C(alpha,alpha)-diethylglycine (Deg)-based peptides have been studied in solution using all atom molecular dynamics simulations. Specifically, the conformational effects of breaking the symmetry of the host Tfa-(Deg)(5)-OtBu (T...

Aminoacylation and translational quality control strategy employed by leucyl-tRNA synthetase from a human pathogen with genetic code ambiguity.

Nucleic Acids Res. 41(21) , 9825-38, (2013)

Aminoacyl-tRNA synthetases should ensure high accuracy in tRNA aminoacylation. However, the absence of significant structural differences between amino acids always poses a direct challenge for some aminoacyl-tRNA synthetases, such as leucyl-tRNA synthetase (...

Continuous β-turn fold of an alternating alanyl/homoalanyl peptide nucleic acid.

Acta Crystallogr. D Biol. Crystallogr. 68(Pt 8) , 1067-70, (2012)

The crystal structure of the PNA (peptide nucleic acid) oligomer H-Lys-HalG-AlaG-HalC-AlaG-HalC-AlaC-Lys-NH(2) (PNA1, amino acids with D-configuration are underlined, Ala = alanyl, Hal = homoalanyl) has been determined by ab initio direct methods and refined ...

Site-selective traceless Staudinger ligation for glycoprotein synthesis reveals scope and limitations.

ChemBioChem. 12(9) , 1383-6, (2011)

Transaminase-catalyzed asymmetric synthesis of L-2-aminobutyric acid from achiral reactants.

Biotechnol. Lett. 31 , 1595-1599, (2009)

Asymmetric synthesis of an unnatural amino acid was demonstrated by omega-transaminase from Vibrio fluvialis JS17. L-2-Aminobutyric acid was synthesized from 2-oxobutyric acid and benzylamine with an enantiomeric excess higher than 99%. The reaction showed se...

Removal of L-alanine from the production of L-2-aminobutyric acid by introduction of alanine racemase and D-amino acid oxidase.

Appl. Microbiol. Biotechnol. 90(3) , 903-10, (2011)

L-2-Aminobutyric acid can be synthesized in a transamination reaction from L-threonine and L-aspartic acid as substrates by the action of threonine deaminase and aromatic aminotransferase, but the by-product L-alanine was produced simultaneously. A small amou...

One carbon metabolism disturbances and the C677T MTHFR gene polymorphism in children with autism spectrum disorders.

J. Cell. Mol. Med. 13(10) , 4229-38, (2009)

Autism spectrum disorders (ASDs), which include the prototypic autistic disorder (AD), Asperger's syndrome (AS) and pervasive developmental disorders not otherwise specified (PDD-NOS), are complex neurodevelopmental conditions of unknown aetiology. The curren...

Crystal structure of the ω-aminotransferase from Paracoccus denitrificans and its phylogenetic relationship with other class III aminotransferases that have biotechnological potential.

Proteins 81(5) , 774-87, (2013)

Apart from their crucial role in metabolism, pyridoxal 5'-phosphate (PLP)-dependent aminotransferases (ATs) constitute a class of enzymes with increasing application in industrial biotechnology. To provide better insight into the structure-function relationsh...