Cerulenin
Cerulenin structure
|
Common Name | Cerulenin | ||
|---|---|---|---|---|
| CAS Number | 17397-89-6 | Molecular Weight | 223.268 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 456.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C12H17NO3 | Melting Point | 93.5℃ | |
| MSDS | Chinese USA | Flash Point | 241.1±25.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
|
Purification and characterization of the Staphylococcus aureus bacillithiol transferase BstA.
Biochim. Biophys. Acta 1840(9) , 2851-61, (2014) Gram-positive bacteria in the phylum Firmicutes synthesize the low molecular weight thiol bacillithiol rather than glutathione or mycothiol. The bacillithiol transferase YfiT from Bacillus subtilis was identified as a new member of the recently discovered Din... |
|
|
Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic melan-a cells associated with inhibition of mitochondrial respiration.
PLoS ONE 9(6) , e101060, (2014) The metabolic enzyme fatty acid synthase (FASN) is responsible for the endogenous synthesis of palmitate, a saturated long-chain fatty acid. In contrast to most normal tissues, a variety of human cancers overexpress FASN. One such cancer is cutaneous melanoma... |
|
|
A Duo of Potassium-Responsive Histidine Kinases Govern the Multicellular Destiny of Bacillus subtilis.
MBio 6 , e00581, (2015) Multicellular biofilm formation and surface motility are bacterial behaviors considered mutually exclusive. However, the basic decision to move over or stay attached to a surface is poorly understood. Here, we discover that in Bacillus subtilis, the key root ... |
|
|
Involvement of de novo synthesized palmitate and mitochondrial EGFR in EGF induced mitochondrial fusion of cancer cells.
Cell Cycle 13(15) , 2415-30, (2014) Increased expressions of fatty acid synthase (FASN) and epidermal growth factor receptor (EGFR) are common in cancer cells. De novo synthesis of palmitate by FASN is critical for the survival of cancer cells via mechanisms independent of its role as an energy... |
|
|
Pregnancy induces resistance to the anorectic effect of hypothalamic malonyl-CoA and the thermogenic effect of hypothalamic AMPK inhibition in female rats.
Endocrinology 156(3) , 947-60, (2015) During gestation, hyperphagia is necessary to cope with the metabolic demands of embryonic development. There were three main aims of this study: Firstly, to investigate the effect of pregnancy on hypothalamic fatty acid metabolism, a key pathway for the regu... |
|
|
The Multiple DSF-family QS Signals are Synthesized from Carbohydrate and Branched-chain Amino Acids via the FAS Elongation Cycle.
Sci. Rep. 5 , 13294, (2015) Members of the diffusible signal factor (DSF) family are a novel class of quorum sensing (QS) signals in diverse Gram-negative bacteria. Although previous studies have identified RpfF as a key enzyme for the biosynthesis of DSF family signals, many questions ... |
|
|
UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis.
J. Clin. Invest. 125(2) , 665-80, (2015) Cellular lipid metabolism has been linked to immune responses; however, the precise mechanisms by which de novo fatty acid synthesis can regulate inflammatory responses remain unclear. The NLRP3 inflammasome serves as a platform for caspase-1-dependent matura... |
|
|
Involvement of acyl-CoA synthetase genes in n-alkane assimilation and fatty acid utilization in yeast Yarrowia lipolytica.
FEMS Yeast Res. 15 , fov031, (2015) Here, we investigated the roles of YAL1 (FAA1) and FAT1 encoding acyl-CoA synthetases (ACSs) and three additional orthologs of ACS genes FAT2-FAT4 of the yeast Yarrowia lipolytica in the assimilation or utilization of n-alkanes and fatty acids. ACS deletion m... |
|
|
Search method for inhibitors of Staphyloxanthin production by methicillin-resistant Staphylococcus aureus.
Biol. Pharm. Bull. 35(1) , 48-53, (2012) Staphyloxanthin, a yellow pigment produced by methicillin-resistant Staphylococcus aureus (MRSA), is a virulent factor escaping from the host immune system. A new screening method for inhibitors of staphyloxanthin production by MRSA was established using pape... |
|
|
Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation.
Oncotarget 6 , 34992-5003, (2015) Epidermal growth factor receptor (EGFR) is an oncogenic receptor tyrosine kinase. Canonically, the tyrosine kinase activity of EGFR is regulated by its extracellular ligands. However, ligand-independent activation of EGFR exists in certain cancer cells, and t... |