3,3'-Diethyloxadicarbocyanine iodide
3,3'-Diethyloxadicarbocyanine iodide structure
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Common Name | 3,3'-Diethyloxadicarbocyanine iodide | ||
|---|---|---|---|---|
| CAS Number | 14806-50-9 | Molecular Weight | 486.34500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H23IN2O2 | Melting Point | 232ºC (dec.)(lit.) | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands
FEBS Lett. 587(11) , 1656-62, (2013) • DODC is more efficient in cell growth inhibition than TMPyP4. • Both DODC and TMPyP4 cause nuclear-mitochondrial shuttling of TERT. • Perturbation of mitochondrial function may account for the toxicity of DODC. |
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Inhibition of mitochondrial and Paracoccus denitrificans NADH-ubiquinone reductase by oxacarbocyanine dyes. A structure-activity study.
Biochem. Pharmacol. 45(10) , 2115-22, (1993) In this study, we determined that three structurally related oxacarbocyanine dyes, 3,3'-diethyloxacarbocyanine (DiOC2(3)), 3,3'-dipentyloxacarbocyanine (DiOC5(3)), and 3,3'-dihexyloxacarbocyanine (DiOC6(3)), and one oxadicarbocyanine, 3,3'-diethyloxadicarbocy... |
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Mix and measure fluorescence screening for selective quadruplex binders.
Nucleic Acids Res. 36 , e106, (2008) The human genome contains thousands of regions, including that of the telomere, that have the potential to form quadruplex structures. Many of these regions are potential targets for therapeutic intervention. There are many different folding patterns for quad... |
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Photophysical and photosensitizing properties of selected cyanines.
J. Photochem. Photobiol. B, Biol. 68(1) , 15-22, (2002) The present work has been carried out to obtain detailed information about the photophysical and photobiological properties of selected cyanines, in view of their possible use as photosensitizing agents. All the cyanines studied by us except CY-IV (3,3'-dieth... |
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Interaction of certain cationic dyes with the respiratory chain of rat liver mitochondria.
J. Biol. Chem. 256(1) , 402-8, (1981) Cationic dyes of the cyanine type have been observed to specifically inhibit NAD-linked respiration in rat liver mitochondria, with 50% inhibition occurring at about 0.2 mumol/g of mitochondrial protein. The dyes show no effect on succinate oxidation or coupl... |
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A G-quadruplex ligand 3,3'-diethyloxadicarbocyanine iodide induces mitochondrion-mediated apoptosis but not decrease of telomerase activity in nasopharyngeal carcinoma NPC-TW01 cells.
Pharm. Res. 21(1) , 93-100, (2004) The G-quadruplex ligand 3,3'-diethyloxadicarbocyanine iodide (DODC) was reported to enhance the apoptotic potency of pheochromocytoma PC-12 and leukemia HL-60 cells through the inhibition of telomerase activity. In this study, a mitochondrion-mediated apoptot... |
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Fluorescent quenching method for determination of trace hydrogen peroxide in rain water.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 67(3-4) , 683-6, (2007) A simple and sensitive fluorescent quenching method for the determination of trace hydrogen peroxide (H(2)O(2)) has been proposed to determine hydrogen peroxide in rain water sample. The method is based on the reaction of H(2)O(2) with 3,3'-diethyloxadicarboc... |
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Vital fluorescent staining technique for microspores of Brassica napus.
Stain Technol. 65(5) , 251-8, (1990) The ontogeny of early microspore-derived embryo development was followed using three stains. The stain 3,3'-diethyloxadicarbocyanine iodide, which previously had been reported to be specific for mitochondria, was observed also to demonstrate the exine of deve... |
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Amino Acid Transport and stimulation by substrates in the absence of a Na2+ electrochemical potential gradient.
J. Membr. Biol. 62(1-2) , 149-60, (1981) Uptake of alpha-aminoisobutyric acid (AIB) was examined in Ehrlich ascites tumor cells treated with the cation-exchange ionophore nigericin (20 microgram/ml). Membrane voltages were measured using the voltage-sensitive dye diethyloxadicarbocyanine (DOCC). In ... |
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Location and orientation of DODCI in lipid bilayer membranes: effects of lipid chain length and unsaturation.
Biochim. Biophys. Acta 1461(1) , 58-68, (1999) The location and orientation of a linear dye molecule, DODCI, in lipid bilayer membrane were determined by the effect of viscosity and refractive index of the aqueous medium on the fluorescence properties of the dye bound to the membrane. The membrane-bound d... |