FEBS Letters 2013-06-05

Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands

Xin-Ying Zhuang, Yong-Gang Yao

Index: FEBS Lett. 587(11) , 1656-62, (2013)

Full Text: HTML

Abstract

• DODC is more efficient in cell growth inhibition than TMPyP4. • Both DODC and TMPyP4 cause nuclear-mitochondrial shuttling of TERT. • Perturbation of mitochondrial function may account for the toxicity of DODC.