Calpain Inhibitor I
Calpain Inhibitor I structure
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Common Name | Calpain Inhibitor I | ||
|---|---|---|---|---|
| CAS Number | 110044-82-1 | Molecular Weight | 383.526 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 632.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H37N3O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 192.9±30.3 °C | |
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Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.
PLoS ONE 10(3) , e0119423, (2015) Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in n... |
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The role of proteases in excitation-contraction coupling failure in muscular dystrophy.
Am. J. Physiol. Cell Physiol. 308(1) , C33-40, (2015) Duchenne muscular dystrophy (DMD) is one of the most frequent types of muscular dystrophy. Alterations in intracellular calcium (Ca(2+)) handling are thought to contribute to the disease severity in DMD, possibly due to the activation of Ca(2+)-activated prot... |
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Necrosis- and apoptosis-related Met cleavages have divergent functional consequences.
Cell Death Dis. 6 , e1769, (2015) Upon activation by its ligand hepatocyte growth factor/scatter factor, the receptor tyrosine kinase Met promotes survival, proliferation, and migration of epithelial cells during embryogenesis. Deregulated Met signaling can also promote cancer progression and... |
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Caspase-dependent cell death-associated release of nucleosome and damage-associated molecular patterns.
Cell Death Dis. 5 , e1494, (2014) Apoptosis, which is anti-inflammatory, and necrosis, which is pro-inflammatory, represent the extremes of the cell death spectrum. Cell death is complex and both apoptosis and necrosis can be observed in the same cells or tissues. Here, we introduce a novel c... |
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Strigolactone analogues induce apoptosis through activation of p38 and the stress response pathway in cancer cell lines and in conditionally reprogrammed primary prostate cancer cells.
Oncotarget 5(6) , 1683-98, (2014) Strigolactones are a novel class of plant hormones produced in roots and regulate shoot and root development. We have previously shown that synthetic strigolactone analogues potently inhibit growth of breast cancer cells and breast cancer stem cells. Here we ... |
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Late-onset of spinal neurodegeneration in knock-in mice expressing a mutant BiP.
PLoS ONE 9(11) , e112837, (2014) Most human neurodegenerative diseases are sporadic, and appear later in life. While the underlying mechanisms of the progression of those diseases are still unclear, investigations into the familial forms of comparable diseases suggest that endoplasmic reticu... |
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Compartmentalization of the chick cerebellar cortex based on the link between the striped expression pattern of aldolase C and the topographic olivocerebellar projection.
J. Comp. Neurol. 523 , 1886-912, (2015) The avian cerebellum is organized into multiple longitudinal stripes defined by expression profiles of aldolase C (zebrin II) in Purkinje cells. The relationship between the aldolase C striped pattern and the olivocerebellar projection pattern is crucial in u... |
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The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif autophagic degradation.
Retrovirology 12 , 53, (2015) Human immunodeficiency virus type 1 (HIV-1) has evolved a complex strategy to overcome the immune barriers it encounters throughout an organism thanks to its viral infectivity factor (Vif), a key protein for HIV-1 infectivity and in vivo pathogenesis. Vif int... |
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BCR-ABL affects STAT5A and STAT5B differentially.
PLoS ONE 9(5) , e97243, (2014) Signal transducers and activators of transcription (STATs) are latent cytoplasmic transcription factors linking extracellular signals to target gene transcription. Hematopoietic cells express two highly conserved STAT5-isoforms (STAT5A/STAT5B), and STAT5 is d... |
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COPI-mediated retrieval of SCAP is crucial for regulating lipogenesis under basal and sterol-deficient conditions.
J. Cell Sci. 128 , 2805-15, (2015) Retrograde trafficking from the Golgi complex to endoplasmic reticulum (ER) through COPI-coated vesicles has been implicated in lipid homeostasis. Here, we find that a block in COPI-dependent retrograde trafficking promotes processing and nuclear translocatio... |