6-AZAURIDINE
6-AZAURIDINE structure
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Common Name | 6-AZAURIDINE | ||
|---|---|---|---|---|
| CAS Number | 54-25-1 | Molecular Weight | 245.19 | |
| Density | 2.1±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C8H11N3O6 | Melting Point | 157-159 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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The lipid moiety of brincidofovir is required for in vitro antiviral activity against Ebola virus.
Antiviral Res. 125 , 71-8, (2016) Brincidofovir (BCV) is the 3-hexadecyloxy-1-propanol (HDP) lipid conjugate of the acyclic nucleoside phosphonate cidofovir (CDV). BCV has established broad-spectrum activity against double-stranded DNA (dsDNA) viruses; however, its activity against RNA viruse... |
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Cytotoxicity of diterpenes from Premna schimperi and Premna oligotricha.
Planta Med. 61(4) , 368-9, (1995) The cytotoxicity of two diterpenes from Premna schimperi and Premna oligotricha (Verbenaceae) was studied using the MTT assay. Their cytotoxic activity against three human (HeLa, SK.N.SH, and ECV 304) and two murine (L929 and RAW 264.7) carcinoma cell lines v... |
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New indications for 6-azauridine treatment in man. A review.
Eur. J. Clin. Pharmacol. 4(2) , 77-81, (1972)
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A simple assay for determining antiviral activity against Crimean-Congo hemorrhagic fever virus.
Antiviral Res. 62(1) , 21-5, (2004) Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus that is emerging as a significant human pathogen in many regions of the world, including Africa, Asia, and Europe. In this report, we describe a simple screening method for discovering new an... |
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Gas chromatographic-mass spectrometric method for analysis of a pyrimido-s-triazine and some of its metabolites in dog urine.
J. Chromatogr. A. 578(1) , 134-40, (1992) 3-Phenylpyrimido-[3,4-a]-s-triazines exhibit antiparasitic, antibacterial and antifungal activity. In order to study the metabolism of these heterocycles, 9,9-diethyl-3-phenyl-6,8-dioxo-2,3,4,5,6,7,8,9-octahydropyrimido[3 ,4-a]-s- triazine (TZ) was administer... |
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Automated analytical systems for drug development studies. V. A system for enzyme kinetic studies.
J. Pharm. Biomed. Anal. 14(12) , 1691-8, (1996) Two similar automated analytical systems using liquid chromatography (LC) and microdialysis as an on-line sampling technique were applied to studies of enzyme kinetics. 2',3',5'-Triacetyl-6-azauridine (azaribine) with porcine liver esterase (PLE) and N-acetyl... |
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Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase.
Nucleosides Nucleotides 17(1-3) , 187-206, (1998) The synthesis and X-ray crystal structures of a series of 5-substituted-6-aza-2'-deoxyuridines is reported. These nucleoside analogues inhibit the phosphorylation of thymidine by HSV-1 TK but have no effect on the corresponding human enzyme. Detailed examinat... |
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Gene amplification and chromosome rearrangements: a study of a single cell lineage selected for amplification and deamplification of the UMP synthase gene.
Cytogenet. Cell Genet. 62(2-3) , 162-8, (1993) The UMP synthase gene is stably amplified in Chinese hamster lung cells selected for resistance to pyrazofurin (PF) and 6-azauridine (6AUR), inhibitors of the decarboxylase activity of the bifunctional UMP synthase enzyme. The amplified DNA is located intrach... |
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Hydrolysis of the prodrug, 2',3',5'-triacetyl-6-azauridine.
Pharm. Res. 12(9) , 1361-70, (1995) The purposes were to study the kinetics of hydrolysis of 2',3',5'-triacetyl-6-azauridine (1) in aqueous solution (mu = 0.5) and to identify the main intermediates and products of the reaction.A stability indicating isocratic LC assay was used to study the rat... |
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Simultaneous determination of 6-azacytidine, 6-azauridine, arabinoside cytosine and arabinoside uracil in blood by liquid chromatography.
J. Pharm. Biomed. Anal. 10(10-12) , 1093-5, (1992)
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