6-AZAURIDINE

Modify Date: 2024-01-03 11:42:50

6-AZAURIDINE structure	Common Name	6-AZAURIDINE
	CAS Number	54-25-1	Molecular Weight	245.19
	Density	2.1±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₈H₁₁N₃O₆	Melting Point	157-159 °C(lit.)
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07, GHS08	Signal Word	Warning

Use of 6-AZAURIDINE

6-Azuridine (6-Azauridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	6-azauridine
Synonym	More Synonyms

Description	6-Azuridine (6-Azauridine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	2.1±0.1 g/cm3
Melting Point	157-159 °C(lit.)
Molecular Formula	C₈H₁₁N₃O₆
Molecular Weight	245.19
Exact Mass	245.064789
PSA	137.67000
LogP	-1.96
Index of Refraction	1.795
Storage condition	2-8°C

6-AZAURIDINE MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY8575000

CHEMICAL NAME :: as-Triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl-

CAS REGISTRY NUMBER :: 54-25-1

BEILSTEIN REFERENCE NO. :: 0032281

LAST UPDATED :: 199709

DATA ITEMS CITED :: 26

MOLECULAR FORMULA :: C8-H11-N3-O6

MOLECULAR WEIGHT :: 245.22

WISWESSER LINE NOTATION :: T6NNVMVJ B- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg/32D-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - leukopenia Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 150 mg/kg

SEX/DURATION :: female 47 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - other effects to embryo

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 84 mg/kg

SEX/DURATION :: female 6-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 252 mg/kg

SEX/DURATION :: female 6-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Specific Developmental Abnormalities - body wall

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 330 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 330 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 900 mg/kg

SEX/DURATION :: female 7-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - abortion

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 900 mg/kg

SEX/DURATION :: female 12-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

DOSE :: 10 gm/kg

SEX/DURATION :: female 14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 6250 mg/kg

SEX/DURATION :: female 3-27 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sperm Morphology

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

REFERENCE :: CEFYAD Ceskoslovenska Fysiologie. (Academia, Vodickova 40, 112 29 Prague 1, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 21,278,1972 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975

Symbol	GHS07, GHS08
Signal Word	Warning
Hazard Statements	H302-H312-H332-H351
Precautionary Statements	P280
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S22-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	XY8575000

6-AZAURIDINE 2'...

CAS#:2169-64-4

~93%

6-AZAURIDINE

CAS#:54-25-1

Literature: Depelley, Jean; Granet, Robert; Kaouadji, Mourad; Krausz, Pierre; Piekarski, Salomon; Delebassee, Sylvie; Bosgiraud, Claudine Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 995 - 1008

6-azauridine 2'...

CAS#:59967-97-4

~88%

6-AZAURIDINE

CAS#:54-25-1

Literature: Drasar, Pavel; Beranek, Jiri Collection of Czechoslovak Chemical Communications, 1987 , vol. 52, # 8 p. 2070 - 2082

6-Azauracil

CAS#:461-89-2

6-AZAURIDINE

CAS#:54-25-1

Literature: Collection of Czechoslovak Chemical Communications, , vol. 22, p. 1330 - 1332

Precursor 3
CAS#:2169-64-4 6-AZAURIDINE 2'... CAS#:59967-97-4 6-azauridine 2'... CAS#:461-89-2 6-Azauracil
DownStream 1
CAS#:2169-64-4 6-AZAURIDINE 2'...

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Brincidofovir (BCV) is the 3-hexadecyloxy-1-propanol (HDP) lipid conjugate of the acyclic nucleoside phosphonate cidofovir (CDV). BCV has established broad-spectrum activity against double-stranded DN...

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New indications for 6-azauridine treatment in man. A review.

Eur. J. Clin. Pharmacol. 4(2) , 77-81, (1972)

6-azur

AZURIDINE

ribo-azuracil

6-azuridine

6-AZAURIDINE

6-aza-uridine

6-Azauracil Ribozide

MFCD00006472

1,2,4-Triazine-3,5(2H,4H)-dione, 2-β-D-ribofuranosyl-

as-Triazine-3,5(2H,4H)-dione, 2-β-D-ribofuranosyl-

2-(β-D-Ribofuranosyl)-1,2,4-triazine-3,5(2H,4H)-dione

6-phosphonouridine 5′-monophosphate

azauridine

azur

EINECS 200-199-6

ribo-Azauracil

2-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2H--[1,2,4]triazine-3,5-dione

2-b-D-Ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,2,4-Triazine-3,5(2H,4H)-dione,2-b-D-ribofuranosyl-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: ￥715/1g

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6-AZAURIDINE

Use of 6-AZAURIDINE

Names

6-AZAURIDINE Biological Activity

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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Articles32

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