N,N',N'',N'''-tetraisopropyldiphosphoramide

N,N',N'',N'''-tetraisopropyldiphosphoramide Structure
N,N',N'',N'''-tetraisopropyldiphosphoramide structure
Common Name N,N',N'',N'''-tetraisopropyldiphosphoramide
CAS Number 513-00-8 Molecular Weight 342.35500
Density 1.076g/cm3 Boiling Point 396.7ºC at 760mmHg
Molecular Formula C12H32N4O3P2 Melting Point 151 °C
MSDS Chinese USA Flash Point 193.7ºC
Symbol GHS06
GHS06
Signal Word Danger

Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

Chem. Biol. Drug Des. 86 , 1168-77, (2015)

A series of scutellarein carbamate derivatives were designed and synthesized based on the multitarget-directed drug design strategy for treatment of Alzheimer's disease. Their acetylcholinesterase and butyrylcholinesterase inhibitory activities, antioxidant a...

Synthetic cannabimimetic agents metabolized by carboxylesterases.

Drug Test. Anal. 7 , 565-76, (2015)

Synthetic cannabimimetic agents are a large group of diverse compounds which act as agonists at cannabinoid receptors. Since 2004, synthetic cannabinoids have been used recreationally, although several of the compounds have been shown to cause severe toxicity...

Higher sensitivity to cadmium induced cell death of basal forebrain cholinergic neurons: A cholinesterase dependent mechanism

Toxicology 325 , 151-9, (2014)

Cadmium is an environmental pollutant, which is a cause of concern because it can be greatly concentrated in the organism causing severe damage to a variety of organs including the nervous system which is one of the most affected. Cadmium has been reported to...

Additive dominant effect of a SOX10 mutation underlies a complex phenotype of PCWH.

Neurobiol. Dis. 80 , 1-14, (2015)

Distinct classes of SOX10 mutations result in peripheral demyelinating neuropathy, central dysmyelinating leukodystrophy, Waardenburg syndrome, and Hirschsprung disease, collectively known as PCWH. Meanwhile, SOX10 haploinsufficiency caused by allelic loss-of...

Evaluation of mechanisms of azinphos-methyl resistance in the codling moth Cydia pomonella (L.).

Arch. Insect Biochem. Physiol. 57(2) , 92-100, (2004)

Resistance of the codling moth Cydia pomonella (L.) to azinphos-methyl is not based on enhanced detoxifying enzymes like oxidation mediated by mixed function oxidases or by glutathione S-transferases. Synergism by S,S,S-tributylphosphoro-trithioate was eviden...

In vitro characterization of cholinesterases in the earthworm Eisenia andrei.

Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 143(4) , 416-21, (2006)

Assessment of pollution impact in soil ecosystems has become a priority and interest has grown concerning the use of invertebrates as sentinel organisms. Inhibition of cholinesterase (ChE) activity has a great potential as a biomarker of pesticide exposure, a...

Characterization of cholinesterase activity from different tissues of Nile tilapia (Oreochromis niloticus).

Mar. Environ. Res. 58(2-5) , 505-9, (2004)

Cholinesterases (ChE) from brain, muscle and liver in Nile tilapia (Oreochromis niloticus) were characterized using three substrates: acetylthiocholine iodide, propionylthiocholine iodide, and butyrylthiocholine iodide. Eserine was used as a total ChE inhibit...

Structural and functional cardiac cholinergic deficits in adult neurturin knockout mice.

Cardiovasc. Res. 82 , 93-9, (2009)

Previous work provided indirect evidence that the neurotrophic factor neurturin (NRTN) is required for normal cholinergic innervation of the heart. This study used nrtn knockout (KO) and wild-type (WT) mice to determine the effect of nrtn deletion on cardiac ...

Optimal detection of cholinesterase activity in biological samples: modifications to the standard Ellman's assay.

Anal. Biochem. 462 , 67-75, (2014)

Ellman's assay is the most commonly used method to measure cholinesterase activity. It is cheap, fast, and reliable, but it has limitations when used for biological samples. The problems arise from 5,5-dithiobis(2-nitrobenzoic acid) (DTNB), which is unstable,...

A novel butyrylcholinesterase from serum ofLeporinus macrocephalus, a Neotropical fish

Biochimie 88(1) , 59-68, (2006)

We show here that serum of piaussu, a Neotropical characin fish, has the highest butyrylcholinesterase activity so far described for humans and fish. To clarify whether this cholinesterase could protect piaussu against anticholinesterase pesticides by scaveng...