thebaine
thebaine structure
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Common Name | thebaine | ||
|---|---|---|---|---|
| CAS Number | 115-37-7 | Molecular Weight | 311.37500 | |
| Density | 1.3g/cm3 | Boiling Point | 467.6ºC at 760mmHg | |
| Molecular Formula | C19H21NO3 | Melting Point | 183-186ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 141ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Ethanol as an alternative to formaldehyde for the enhancement of manganese(IV) chemiluminescence detection.
Talanta 130 , 221-5, (2014) Previous applications of manganese(IV) as a chemiluminescence reagent have required the use of formaldehyde to enhance the emission intensity to analytically useful levels. However, this known human carcinogen (by inhalation) is not ideal for routine applicat... |
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Fatality involving the ingestion of phenazepam and poppy seed tea.
J. Anal. Toxicol. 34(8) , 527-32, (2010) Phenazepam is a benzodiazepine derivative that has been in clinical use in Russia since 1978 and is not available by prescription in the United States; however, it is attainable through various internet websites, sold either as tablets or as a reference grade... |
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Recent developments in the chemistry of thebaine and its transformation products as pharmacological targets.
Curr. Med. Chem. 16(25) , 3215-42, (2009) The most practical synthetic routes to the preparation of as important pharmaceuticals as oxycodone, naloxone, naltrexone, nalbuphine and buprenorphine have utilized the alkaloid, thebaine, as a starting material. This review intends to focus on chemical tran... |
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Thebaine in hair as a marker for chronic use of illegal opium poppy substances.
Forensic Sci. Int. 204(1-3) , 115-8, (2011) Opium poppy products are often illegally used for both recreational and medicinal purposes. In order to demonstrate the ingestion of opium poppy substances, morphine, codeine and their metabolites have been identified. However, morphine and codeine also origi... |
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Separation and determination of five major opium alkaloids with mixed mode of hydrophilic/cation-exchange monolith by pressurized capillary electrochromatography.
J. Sep. Sci. 30(17) , 3011-7, (2007) A method for the separation and determination of five major opium alkaloids (narcotine, papaverine, thebaine, codeine, and morphine) in pericarpium papaveris by pressurized CEC (pCEC) with monolithic column has been developed. Under the optimum condition, lin... |
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Synthesis of buprenorphine from oripavine via N-demethylation of oripavine quaternary salts.
J. Org. Chem. 76(11) , 4628-34, (2011) Buprenorphine was synthesized from oripavine by a sequence involving the conversion of oripavine into its cyclopropylmethyl quaternary salt, N-demethylation with thiolate to N-cyclopropylmethyl nororipavine, and conversion of this material to the title compou... |
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Cinnamoyl derivatives of 7alpha-aminomethyl-6,14-endo-ethanotetrahydrothebaine and 7alpha-aminomethyl-6,14-endo-ethanotetrahydrooripavine and related opioid ligands.
J. Med. Chem. 50(21) , 5176-82, (2007) A new series of ligands has been synthesized where the cinnamoyl group of the 14-cinnamoylamino morphinones has been introduced to the 7alpha-substituent of the 6,14-bridged oripavine series. In vitro the compounds were mostly low efficacy partial agonists or... |
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Rat CYP2D2, not 2D1, is functionally conserved with human CYP2D6 in endogenous morphine formation
FEBS Lett. 586(13) , 1749-53, (2012) Highlights ► Activity of rat CYP2D1 and 2D2 with three morphine precursors was tested. ► Thebaine and codeine were 3-O-demethylated by CYP2D2, not 2D1. ► CYP2D2 generated four phenol-coupled products from (R)-reticuline. ► CYP2D1 was completely inactive with ... |
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Analysis of fluid extracts obtained from Papaver rhoeas petals contaminated with Papaver bracteatum petals.
Planta Med. 78(12) , 1395-8, (2012) In this paper, we report a case of misidentification of medicinal plants involving dried petals of Papaver rhoeas (red poppy) contaminated with Papaver bracteatum (scarlet poppy) petals. Preliminary TLC analysis indicated the presence of thebaine either in th... |
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Consensus 3D model of μ-opioid receptor ligand efficacy based on a quantitative Conformationally Sampled Pharmacophore.
J. Phys. Chem. B 115(22) , 7487-96, (2011) Despite being studied for over 30 years, a consensus structure-activity relationship (SAR) that encompasses the full range peptidic and nonpeptidic μ-opioid receptor ligands is still not available. To achieve a consensus SAR the Conformationally Sampled Pharm... |