FEBS Letters 2012-06-21

Rat CYP2D2, not 2D1, is functionally conserved with human CYP2D6 in endogenous morphine formation

Nadja Grobe, Toni M. Kutchan, Meinhart H. Zenk, Nadja Grobe, Toni M Kutchan, Meinhart H Zenk, Nadja Grobe, Toni M Kutchan, Meinhart H Zenk

Index: FEBS Lett. 586(13) , 1749-53, (2012)

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Abstract

Highlights ► Activity of rat CYP2D1 and 2D2 with three morphine precursors was tested. ► Thebaine and codeine were 3-O-demethylated by CYP2D2, not 2D1. ► CYP2D2 generated four phenol-coupled products from (R)-reticuline. ► CYP2D1 was completely inactive with (R)-reticuline. ► CYP2D2 showed high catalytic efficiencies for the three human CYP2D6 substrates.