6-(trifluoromethyl)pyrimidin-4-ol

6-(trifluoromethyl)pyrimidin-4-ol Structure
6-(trifluoromethyl)pyrimidin-4-ol structure
Common Name 6-(trifluoromethyl)pyrimidin-4-ol
CAS Number 1546-78-7 Molecular Weight 164.085
Density 1.5±0.1 g/cm3 Boiling Point 229.0±35.0 °C at 760 mmHg
Molecular Formula C5H3F3N2O Melting Point 169-171 °C(lit.)
MSDS Chinese USA Flash Point 92.3±25.9 °C
Symbol GHS07
GHS07
Signal Word Warning

Synthesis and antitumor activity of novel 10-substituted camptothecin analogues.

Bioorg. Med. Chem. 14(21) , 7175-82, (2006)

In an attempt to improve the antitumor activity and decrease the cytotoxicity of camptothecin, 18 new 10-substituted camptothecin derivatives were prepared. The cytotoxicity in vitro on cancer cell lines and antitumor activity in vivo, and inhibitory properti...