Flumazenil
Flumazenil structure
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Common Name | Flumazenil | ||
|---|---|---|---|---|
| CAS Number | 78755-81-4 | Molecular Weight | 303.288 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 528.0±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H14FN3O3 | Melting Point | 201-203°C | |
| MSDS | Chinese USA | Flash Point | 273.1±30.1 °C | |
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Tonic current through GABAA receptors and hyperpolarization-activated cyclic nucleotide-gated channels modulate resonance properties of rat subicular pyramidal neurons.
Eur. J. Neurosci. 40(1) , 2241-54, (2014) The subiculum, considered to be the output structure of the hippocampus, modulates information flow from the hippocampus to various cortical and sub-cortical areas such as the nucleus accumbens, lateral septal region, thalamus, nucleus gelatinosus, medial nuc... |
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Mild Staphylococcus aureus Skin Infection Improves the Course of Subsequent Endogenous S. aureus Bacteremia in Mice.
PLoS ONE 10 , e0129150, (2015) Staphylococcus aureus carriers with S. aureus bacteremia may have a reduced mortality risk compared to non-carriers. A role for the immune system is suggested. Here, we study in mice the effect of mild S. aureus skin infection prior to endogenous or exogenous... |
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PET molecular imaging to investigate higher brain dysfunction in patients with neurotrauma.
Acta Neurochir. Suppl. 118 , 251-4, (2013) Many neurotrauma patients suffer from higher brain dysfunction even when focal brain damage is not detected with MRI. We performed functional imaging with positron emission tomography (PET) to clarify the relationship between the functional deficit and sympto... |
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Cortical oscillatory dynamics and benzodiazepine-site modulation of tonic inhibition in fast spiking interneurons.
Neuropharmacology 95 , 192-205, (2015) Tonic conductance mediated by extrasynaptic GABAA receptors has been implicated in the modulation of network oscillatory activity. Using an in vitro brain slice to produce oscillatory activity and a kinetic model of GABAA receptor dynamics, we show that chang... |
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Effect of small molecule vasopressin V1a and V2 receptor antagonists on brain edema formation and secondary brain damage following traumatic brain injury in mice.
J. Neurotrauma 32(4) , 221-7, (2015) The attenuation of brain edema is a major therapeutic target after traumatic brain injury (TBI). Vasopressin (AVP) is well known to play a major role in the regulation of brain water content and vasoendothelial functions and to be involved in brain edema form... |
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GABA(A) receptor modulation and neuropharmacological activities of viscosine isolated from Dodonaea viscosa (Linn).
Pharmacol. Biochem. Behav. 136 , 64-72, (2015) The objective of the present study was to evaluate the modulation of GABA-evoked currents by the flavonoid viscosine at recombinant GABA(A) receptors, and subsequently to study its anxiolytic, sedative and anticonvulsant activities. Viscosine (1-300μM) positi... |
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Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system.
Fitoterapia 96 , 123-30, (2014) The fruits of Schisandra chinensis have been used for the treatment of insomnia in oriental countries for more than thousands of years. However, the pharmacological properties and the mechanism of sedative and hypnotic effects have not yet been studied. Gomis... |
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Evaluation of anxiolytic activity of compound Valeriana jatamansi Jones in mice.
BMC Complement Altern. Med. 12 , 223, (2012) Compound Valeriana jatamansi Jones is a formula for treating anxiety-related diseases in the clinic, which is composed of Valeriana jatamansi Rhizoma et Radix, Ziziphi Spinosae Semen, Albiziae Cortex and Junci Medulla. The purpose of this study was to explore... |
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Acute tolerance to chlordiazepoxide qualitatively changes the interaction between flumazenil and pregnanolone and not the interaction between flumazenil and midazolam in rhesus monkeys discriminating midazolam.
Eur. J. Pharmacol. 700(1-3) , 159-64, (2013) Benzodiazepines and neuroactive steroids act at distinct binding sites on γ-aminobutyric acid(A) (GABA(A)) receptors where they positively modulate GABA, resulting in similar acute behavioral effects. Tolerance to benzodiazepines can develop with repeated tre... |
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First-degree atrioventricular block in alprazolam overdose reversed by flumazenil.
J. Pharm. Pharmacol. 51(3) , 367-70, (1999) This report describes a case of alprazolam overdose associated with marked first-degree atrioventricular block reversed by flumazenil. Animal and human evidence suggests activity of certain benzodiazepines at peripheral benzodiazepine receptors in the myocard... |