Rofecoxib
Rofecoxib structure
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Common Name | Rofecoxib | ||
|---|---|---|---|---|
| CAS Number | 162011-90-7 | Molecular Weight | 314.356 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 577.6±50.0 °C at 760 mmHg | |
| Molecular Formula | C17H14O4S | Melting Point | 207°C | |
| MSDS | Chinese USA | Flash Point | 303.1±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models.
Arch. Pharm. Res. 38 , 813-25, (2015) 4-O-methylhonokiol (MH) is known to inhibit inflammation by partially understood mechanisms. Here, the anti-inflammatory mechanisms of MH were examined using enzymatic, cellular, and animal assays. In enzymatic assays, MH inhibited COX-2 activity with an IC50... |
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Celecoxib increases lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1.
Oncotarget 6 , 39342-56, (2015) The antitumorigenic mechanism of the selective cyclooxygenase-2 (COX-2) inhibitor celecoxib is still a matter of debate. Using lung cancer cell lines (A549, H460) and metastatic cells derived from a lung cancer patient, the present study investigates the impa... |
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A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity
Toxicol. Lett. 230(3) , 382-92, (2014) • Current hERG assays remain insensitive as predictors of clinical toxicity. • We have developed a state-of-art computational model of hERG blocking. • The method was validated using two biological assays of functional hERG blocking. • As an example the anti-... |
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Is the full potential of the biopharmaceutics classification system reached?
Eur. J. Pharm. Sci. 57 , 224-31, (2014) In this paper we analyse how the biopharmaceutics classification system (BCS) has been used to date. A survey of the literature resulted in a compilation of 242 compounds for which BCS classes were reported. Of these, 183 compounds had been reported to belong... |
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In vivo and in vitro anti-inflammatory activity of Cryptostegia grandiflora Roxb. ex R. Br. leaves.
Biol. Res. 47 , 32, (2014) Despite Cryptostegia grandiflora Roxb. ex R. Br. (Apocynaceae) leaves are widely used in folk Caribbean Colombian medicine for their anti-inflammatory effects, there are no studies that support this traditional use. Therefore, this work aimed to evaluate the ... |
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Ultrahigh-performance liquid chromatography/tandem mass spectrometry method for evaluating enzyme activity and screening inhibitors of cyclooxygenase-2.
Rapid Commun. Mass Spectrom. 28(16) , 1792-800, (2015) Prostaglandin E2 is an important biomarker in many biological systems. The development of sensitive and reliable analytical methods for monitoring PGE2 contents in various samples is of great interest. Here we developed an improved method for evaluating the e... |
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The Expected Net Present Value of Developing Weight Management Drugs in the Context of Drug Safety Litigation.
Pharmacoeconomics 33 , 749-63, (2015) Following withdrawals, failures, and significant litigation settlements, drug product launches in the anti-obesity category slowed despite a large and growing unmet need. Litigation concerns, a more risk-averse regulatory policy, and the difficulty of develop... |
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Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
Lancet 382(9894) , 769-79, (2013) The vascular and gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs), including selective COX-2 inhibitors (coxibs) and traditional non-steroidal anti-inflammatory drugs (tNSAIDs), are not well characterised, particularly in patients at... |
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Endogenous prostaglandins and afferent sensory nerves in gastroprotective effect of hydrogen sulfide against stress-induced gastric lesions.
PLoS ONE 10(3) , e0118972, (2015) Hydrogen sulfide (H2S) plays an important role in human physiology, exerting vasodilatory, neuromodulatory and anti-inflammatory effects. H2S has been implicated in the mechanism of gastrointestinal integrity but whether this gaseous mediator can affect hemor... |
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AM251 induces apoptosis and G2/M cell cycle arrest in A375 human melanoma cells.
Anticancer Drugs 26 , 754-62, (2015) Human cutaneous melanoma is an aggressive and chemotherapy-resistant type of cancer. AM251 is a cannabinoid type 1 (CB1) receptor antagonist/inverse agonist with off-target antitumor activity against pancreatic and colon cancer cells. The current study aimed ... |