Maleimide
Maleimide structure
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Common Name | Maleimide | ||
|---|---|---|---|---|
| CAS Number | 541-59-3 | Molecular Weight | 97.072 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 264.4±23.0 °C at 760 mmHg | |
| Molecular Formula | C4H3NO2 | Melting Point | 91-93 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 113.7±22.6 °C | |
| Symbol |
GHS05, GHS06 |
Signal Word | Danger | |
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Lateral opening of the bacterial translocon on ribosome binding and signal peptide insertion.
Nat. Commun. 5 , 5263, (2014) Proteins are co-translationally inserted into the bacterial plasma membrane via the SecYEG translocon by lateral release of hydrophobic transmembrane segments into the phospholipid bilayer. The trigger for lateral opening of the translocon is not known. Here ... |
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Identification of inhibitors of a bacterial sigma factor using a new high-throughput screening assay.
Antimicrob. Agents Chemother. 59(1) , 193-205, (2014) Gram-negative bacteria are formidable pathogens because their cell envelope presents an adaptable barrier to environmental and host-mediated challenges. The stress response pathway controlled by the alternative sigma factor σ(E) is critical for maintenance of... |
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Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.
Biochem. Biophys. Res. Commun. 456(1) , 116-21, (2014) G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins, and they are considered major targets of approximately half of all therapeutic agents. Human melanocortin-4 receptor (hMC4R) plays an important role in the c... |
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Synthesis of folate- pegylated polyester nanoparticles encapsulating ixabepilone for targeting folate receptor overexpressing breast cancer cells.
J. Mater. Sci. Mater. Med. 26 , 275, (2015) The aim of this study was the preparation of novel polyester nanoparticles based on folic acid (FA)-functionalized poly(ethylene glycol)-poly(propylene succinate) (PEG-PPSu) copolymer and loaded with the new anticancer drug ixabepilone (IXA). These nanopartic... |
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Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.
Protein Sci. 24(4) , 446-63, (2015) Ebolaviruses are highly lethal filoviruses that cause hemorrhagic fever in humans and nonhuman primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponizat... |
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Point-of-Care Quantitative Measure of Glucose-6-Phosphate Dehydrogenase Enzyme Deficiency.
Pediatrics 136 , e1268-75, (2015) Widespread newborn screening on a point-of-care basis could prevent bilirubin neurotoxicity in newborns with glucose-6-phosphate dehydrogenase (G6PD) deficiency. We evaluated a quantitative G6PD assay on a digital microfluidic platform by comparing its perfor... |
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Silane-coated magnetic nanoparticles with surface thiol functions for conjugation with gold nanostars.
Dalton Trans. 44 , 21088-98, (2015) Small (d∼ 8 nm) magnetite nanoparticles, Fe3O4NP, are prepared and coated with mercaptopropyl trimethoxysilane (MPTS) to form Fe3O4NP@MPTS. In the coating step controlled MPTS/Fe3O4NP molar ratios are used, ranging from 1 to 7.8 × 10(4). The total quantity of... |
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FASCIN and alpha-actinin can regulate the conformation of actin filaments.
Biochim. Biophys. Acta 1850 , 1855-61, (2015) Actin filament bundling proteins mediate numerous processes in cells such as the formation of cell membrane protrusions or cell adhesions and stress fiber based locomotion. Among them alpha-actinin and fascin are the most abundant ones. This work characterize... |
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Implementing visible 473 nm photodissociation in a Q-Exactive mass spectrometer: towards specific detection of cysteine-containing peptides.
Analyst 139(21) , 5523-30, (2014) Improvement of the fragmentation specificity may streamline data processing of bottom-up proteomic experiments by drastically reducing either the amount of MS/MS data to process in the discovery phase or the detection of interfering signals in targeted quanti... |
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Molecular factors in dendritic cell responses to adsorbed glycoconjugates.
Biomaterials 35(22) , 5862-74, (2014) Carbohydrates and glycoconjugates have been shown to exert pro-inflammatory effects on the dendritic cells (DCs), supporting pathogen-induced innate immunity and antigen processing, as well as immunosuppressive effects in the tolerance to self-proteins. Addit... |