Miconazole
Miconazole structure
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Common Name | Miconazole | ||
|---|---|---|---|---|
| CAS Number | 22916-47-8 | Molecular Weight | 416.129 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 555.1±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H14Cl4N2O | Melting Point | 159-163ºC | |
| MSDS | N/A | Flash Point | 289.5±30.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Simultaneous determination of seven azole antifungal drugs in serum by ultra-high pressure liquid chromatography and diode array detection.
Acta Clin. Belg. 69(1) , 53-61, (2014) Azole antifungals are a group of fungistatic agents that can be administered orally or parenterally. The determination of the concentrations of these antifungals (miconazole, fluconazole, ketoconazole, posaconazole, voriconazole, itraconazole, and its major a... |
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A comparison of in vitro ADME properties and pharmacokinetics of azithromycin and selected 15-membered ring macrolides in rodents.
Eur. J. Drug Metab. Pharmacokinet. 39(4) , 263-76, (2014) The purpose of this study was to evaluate the impact of structural modifications on the 15-membered macrolactone ring and/or substituents on the in vitro ADME properties and in vivo pharmacokinetic (PK) profile for selected derivatives in rodents in compariso... |
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HPLC and chemometric methods for the simultaneous determination of miconazole nitrate and nystatin.
J. Chromatogr. Sci. 50(10) , 855-61, (2012) High-performance liquid chromatography (HPLC) and chemometric methods were applied to the simultaneous determination of the two nonsteroidal antifungal drugs, miconazole (MIC) and nystatin (NYS). The applied chemometric techniques are multivariate methods inc... |
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Peel bond strength of resilient liner modified by the addition of antimicrobial agents to denture base acrylic resin.
J. Appl. Oral Sci. 20(6) , 607-12, (2012) In order to prolong the clinical longevity of resilient denture relining materials and reduce plaque accumulation, incorporation of antimicrobial agents into these materials has been proposed. However, this addition may affect their properties. |
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Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants.
Cochrane Database Syst. Rev. 3 , CD003478, (2013) Invasive fungal infection is an important cause of mortality and morbidity in very preterm or very low birth weight infants. Uncertainty exists about the effect of prophylactic oral/topical non-absorbed antifungals to reduce mucocutaneous colonisation and so ... |
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In vitro antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans.
J. Contemp. Dent. Pract. 13(5) , 695-8, (2012) To determine and compare antifungal activity of two tissue conditioners combined with nystatin, miconazole and fluconazole against Candida albicans.Two tissue conditioners Viscogel and GC Soft combined with nystatin, miconazole and fluconazole were tested aga... |
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Cytochrome P450 OxyBtei catalyzes the first phenolic coupling step in teicoplanin biosynthesis.
ChemBioChem. 15(18) , 2719-28, (2014) Bacterial cytochrome P450s form a remarkable clade of the P450 superfamily of oxidative hemoproteins, and are often involved in the biosynthesis of complex natural products. Those in a subgroup known as "Oxy enzymes" play a crucial role in the biosynthesis of... |
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A genetic and pharmacological analysis of isoprenoid pathway by LC-MS/MS in fission yeast.
PLoS ONE 7(11) , e49004, (2012) Currently, statins are the only drugs acting on the mammalian isoprenoid pathway. The mammalian genes in this pathway are not easily amenable to genetic manipulation. Thus, it is difficult to study the effects of the inhibition of various enzymes on the inter... |
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Phosphatidylinositol binding of Saccharomyces cerevisiae Pdr16p represents an essential feature of this lipid transfer protein to provide protection against azole antifungals.
Biochim. Biophys. Acta 1842(10) , 1483-90, (2014) Pdr16p is considered a factor of clinical azole resistance in fungal pathogens. The most distinct phenotype of yeast cells lacking Pdr16p is their increased susceptibility to azole and morpholine antifungals. Pdr16p (also known as Sfh3p) of Saccharomyces cere... |
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Formulation and drying of miconazole and itraconazole nanosuspensions.
Int. J. Pharm. 443(1-2) , 209-20, (2013) Miconazole and itraconazole possess adequate membrane permeability, but only slight water solubility, which limits their bioavailability and antifungal effect. To increase their dissolution rate, the compounds were nanoground by media milling to produce nanos... |