2,6-Dihydroxyacetophenone
2,6-Dihydroxyacetophenone structure
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Common Name | 2,6-Dihydroxyacetophenone | ||
|---|---|---|---|---|
| CAS Number | 699-83-2 | Molecular Weight | 152.147 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 262.8±20.0 °C at 760 mmHg | |
| Molecular Formula | C8H8O3 | Melting Point | 156-158 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 127.0±18.3 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Molecular modeling and inhibition of phospholipase A2by polyhydroxy phenolic compounds
Eur. J. Med. Chem. 44 , 312-21, (2009) Phospholipases A 2 are enzymes responsible for the hydrolysis of membrane phospholipids that release arachidonic acid, which serves as substrate for pro-inflammatory mediators, such as prostaglandins and leucotriens. The design of specific inhibitors for PLA ... |
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Novel squalene-hopene cyclase inhibitors derived from hydroxycoumarins and hydroxyacetophenones.
Chem. Pharm. Bull. 52(10) , 1171-4, (2004) Squalene-hopene cyclase (SHC) is a useful model enzyme for predicting molecular interactions with oxidosqualene cyclase (OSC). Structure--activity relationships were investigated for numerous coumarin-derived inhibitors of SHC, and structural simplifications ... |
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MALDI mass spectrometry in the solution of some forensic problems.
Forensic Sci. Int. 146 Suppl , S83-5, (2004)
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Study of the acute human health effects of intermediates in the synthesis of sodium cromoglycate.
Ann. Occup. Hyg. 39(2) , 235-40, (1995) Sodium cromoglycate is manufactured by a seven-stage synthetic process. There has been no previous documentation of toxicological effects of the intermediate compounds in its synthesis. This paper describes the health effects of acute exposure to the intermed... |
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Enhanced MALDI-TOF MS analysis of phosphopeptides using an optimized DHAP/DAHC matrix.
J. Biomed. Biotechnol. 2010 , 759690, (2010) Selecting an appropriate matrix solution is one of the most effective means of increasing the ionization efficiency of phosphopeptides in matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). In this study, we systematic... |
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Inhibitory effects of choleretic hydroxyacetophenones on ileal bile acid transport in rats.
Life Sci. 78(14) , 1630-6, (2006) The effects of the choleretic and cholesterol lowering compound, 2,4,6-trihydroxyacetophenone (THA) and its analog, 2,6-dihydroxyacetophenone (DHA), on ileal bile acid absorption were investigated in rats. THA inhibited taurocholate (TC) uptake into ileal bru... |
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Oligosaccharide characterization and quantitation using 1-phenyl-3-methyl-5-pyrazolone derivatization and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Anal. Biochem. 248 , 63-75, (1997) The 1-phenyl-3-methyl-5-pyrazolone (PMP) derivatives of monosaccharides, maltooligosaccharides, and oligosaccharides enzymatically released from asparagine-linked sites in ribonuclease B and fetuin have been investigated using matrix-assisted laser desorption... |
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Direct MALDI-MS analysis of cardiolipin from rat organs sections.
J. Am. Soc. Mass Spectrom. 18 , 567-577, (2007) Cardiolipins (CL) are mitochondria specific lipids. They play a critical role in ATP synthesis mediated by oxidative phosphorylation. Abnormal CL distribution is associated with several disease states. MALDI-MS and MALDI-MS/MS were used to demonstrate in situ... |
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Use of 2,6-dihydroxyacetophenone for analysis of fragile peptides, disulphide bonding and small proteins by matrix-assisted laser desorption/ionization.
Rapid Commun. Mass Spectrom. 10 , 529-536, (1996) Several peptides were shown to undergo fragmentation during matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to a degree which complicated their analysis using alpha-cyano-4-hydroxycinnamic acid (CHCA) as a matrix, even at threshol... |
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The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids.
Biochem. Biophys. Res. Commun. 295(1) , 9-13, (2002) Phloretin is a dihydrochalcone flavonoid that displays a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation. Comparison with structurally related compounds revealed that the antioxidant pharmacophore of phloretin ... |