Methylphosphonic acid
Methylphosphonic acid structure
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Common Name | Methylphosphonic acid | ||
|---|---|---|---|---|
| CAS Number | 993-13-5 | Molecular Weight | 96.022 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 265.2±23.0 °C at 760 mmHg | |
| Molecular Formula | CH5O3P | Melting Point | 103-105ºC | |
| MSDS | Chinese USA | Flash Point | 114.2±22.6 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Determination of nerve agent degradation products by capillary electrophoresis using field-amplified sample stacking injection with the electroosmotic flow pump and contactless conductivity detection.
J. Chromatogr. A. 1216(31) , 5911-6, (2009) In the present study, field-amplified sample stacking injection using the electroosmotic flow pump (FAEP) was developed for the capillary electrophoretic separation of the four nerve agent degradation products methylphosphonic acid (MPA), ethyl methylphosphon... |
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Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with organic phosphates and phosphonates.
Bioorg. Med. Chem. Lett. 15 , 1683-6, (2005) The interaction of five human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes, that is, hCA I, II, IV, V, and IX with a small library of phosphonic acids/organic phosphates, including methylphosphonic acid, MPA; phenylphosphonic acid, PPA; N-(phosphonoacetyl)-L... |
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p-Tolyl isocyanate derivatization for analysis of CWC-related polar degradation products by mass spectrometry.
Anal. Bioanal. Chem 406(21) , 5093-102, (2014) Most of the precursors and/or degradation products related to the Chemical Weapons Convention (CWC) are polar. Identification of these molecules in environmental samples provides clues regarding the alleged usage and/or synthesis of the parent toxic chemicals... |
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Functional annotation and three-dimensional structure of an incorrectly annotated dihydroorotase from cog3964 in the amidohydrolase superfamily.
Biochemistry 52(1) , 228-38, (2013) The substrate specificities of two incorrectly annotated enzymes belonging to cog3964 from the amidohydrolase superfamily were determined. This group of enzymes are currently misannotated as either dihydroorotases or adenine deaminases. Atu3266 from Agrobacte... |
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Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.
ChemMedChem 6(5) , 922-35, (2011) Autotaxin (ATX, NPP2) is a member of the nucleotide pyrophosphate phosphodiesterase enzyme family. ATX catalyzes the hydrolytic cleavage of lysophosphatidylcholine (LPC) by lysophospholipase D activity, which leads to generation of the growth-factor-like lipi... |
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DNA translocation by human uracil DNA glycosylase: role of DNA phosphate charge.
Biochemistry 52(15) , 2526-35, (2013) Human DNA repair glycosylases must encounter and inspect each DNA base in the genome to discover damaged bases that may be present at a density of <1 in 10 million normal base pairs. This remarkable example of specific molecular recognition requires a reduced... |
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Mechanism and transition state structure of aryl methylphosphonate esters doubly coordinated to a dinuclear cobalt(III) center.
J. Am. Chem. Soc. 131(35) , 12771-9, (2009) Reactivities of five phosphonate esters each coordinated to a dinuclear Co(III) complex were investigated ([Co(2)(tacn)(2)(OH)(2){O(2)P(Me)OAr}](3+); tacn = 1,4,7-triazacyclononane; substituent = m-F, p-NO(2) (1a); p-NO(2) (1b); m-NO(2) (1c); p-Cl (1d); unsub... |
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Quantitative analysis of chemical warfare agent degradation products in beverages by liquid chromatography tandem mass spectrometry.
J. Agric. Food Chem. 57(18) , 8227-35, (2009) Though chemical warfare agents (CWAs) have been banned by the Chemical Weapons Convention, the threat that such chemicals may be used, including their deliberate addition to food, remains. In such matrixes, CWAs may hydrolyze to phosphonic acids, which are go... |
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Distribution of glyphosate and methylphosphonate catabolism systems in soil bacteria Ochrobactrum anthropi and Achromobacter sp.
Appl. Microbiol. Biotechnol. 93(2) , 787-96, (2012) Bacterial strains capable of utilizing methylphosphonic acid (MP) or glyphosate (GP) as the sole sources of phosphorus were isolated from soils contaminated with these organophosphonates. The strains isolated from MP-contaminated soils grew on MP and failed t... |
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Active site electrostatics protect genome integrity by blocking abortive hydrolysis during DNA recombination.
EMBO J. 28(12) , 1745-56, (2009) Water, acting as a rogue nucleophile, can disrupt transesterification steps of important phosphoryl transfer reactions in DNA and RNA. We have unveiled this risk, and identified safeguards instituted against it, during strand cleavage and joining by the tyros... |