Nialamide
Nialamide structure
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Common Name | Nialamide | ||
|---|---|---|---|---|
| CAS Number | 51-12-7 | Molecular Weight | 298.34000 | |
| Density | 1.203g/cm3 | Boiling Point | 538.1ºC at 760mmHg | |
| Molecular Formula | C16H18N4O2 | Melting Point | 152-154ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 279.2ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Warning | |
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Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for determination of isoniazid in human plasma.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877(3) , 285-90, (2009) An LC-MS/MS method for the determination of isoniazid in human plasma was developed and validated. Human plasma aliquots of 100 microL were used for analysis. The assay used nialamide as the internal standard. The calibration curve concentration range was 50-... |
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UWA-121, a mixed dopamine and serotonin re-uptake inhibitor, enhances L-DOPA anti-parkinsonian action without worsening dyskinesia or psychosis-like behaviours in the MPTP-lesioned common marmoset.
Neuropharmacology 82 , 76-87, (2014) L-3,4-Dihydroxyphenylalanine (L-DOPA) is the most effective treatment for Parkinson's disease (PD), but its long-term administration is complicated by wearing-off and dyskinesia. UWA-101, a dual, equipotent inhibitor of dopamine (DAT) and serotonin (SERT) tra... |
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Spinal cord injury enables aromatic L-amino acid decarboxylase cells to synthesize monoamines.
J. Neurosci. 34(36) , 11984-2000, (2014) Serotonin (5-HT), an important modulator of both sensory and motor functions in the mammalian spinal cord, originates mainly in the raphe nuclei of the brainstem. However, following complete transection of the spinal cord, small amounts of 5-HT remain detecta... |
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Ultrastructural localization of sympathetic axons in experimental rat sciatic nerve neuromas.
J. Neurocytol. 25(10) , 573-82, (1996) The ultrastructural localization of sympathetic axons was investigated in normal rat sciatic nerves and experimental sciatic nerve neuromas. The best ultrastructural localization of noradrenaline in the dense-cored vesicles of sympathetic axons was accomplish... |
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Preproenkephalin knockout mice show no depression-related phenotype.
Biol. Psychiatry 32(11) , 2330-7, (2007) Clinical, preclinical, and pharmacological studies have suggested that decreased enkephalin tone is associated with depression-like symptoms and increase in enkephalin signaling could have a therapeutic value in the treatment of depression. In this study we d... |
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5-Hydroxytryptamine-immunoreactive nerve fibers in the rat and porcine prevertebral sympathetic ganglia: effect of precursor loading and relation to catecholaminergic neurons.
Neurosci. Lett. 194(1-2) , 85-8, (1995) Localization of 5-hydroxytryptamine immunoreactivity was studied in the rat coeliac-superior mesenteric ganglion complex and in the porcine superior and inferior mesenteric ganglia by the indirect immunofluorescence technique. In normal rats, only 5-hydroxytr... |
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Serotonergic and non-serotonergic projections from the raphe nuclei to the piriform cortex in the rat: a cholera toxin B subunit (CTb) and 5-HT immunohistochemical study.
Brain Res. 671(1) , 27-37, (1995) Retrograde axonal transport of the cholera toxin B subunit (CTb) was combined with 5-HT immunohistochemistry to determine the origin of the serotonergic innervation of the piriform cortex (PC) in the rat. After iontophoretic CTb injections in the PC, a substa... |
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Parallel nociceptive reflex pathways with negative and positive feedback functions to foot extensors in the cat.
J. Physiol. 536(Pt 2) , 605-13, (2001) 1. Nociceptive reflex pathways to foot extensors were investigated with particular attention given to those not following a flexor reflex (FRA) or withdrawal pattern. 2. In anaemically decapitated, high spinal paralysed cats nociceptive afferents of the foot ... |
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Sources of reactive oxygen species production in excitotoxin- stimulated cerebellar granule cells.
Biochem. Biophys. Res. Commun. 256(2) , 320-4, (1999) Reactive oxygen species (ROS) production in rat cerebellar granule cells in the presence of the excitotoxins N-methyl-d-aspartate (NMDA) and kainic acid (KA) and by the protein kinase C activator phorbol myristate acetate (PMA) was Ca2+-dependent and resulted... |
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[Modulation of transcranial electroanalgesia by effecting the serotoninergic system of the brain].
Dokl. Akad. Nauk. 347(2) , 275-7, (1996)
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