(+/-)-4-HYDROXYDEBRISOQUIN
(+/-)-4-HYDROXYDEBRISOQUIN structure
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Common Name | (+/-)-4-HYDROXYDEBRISOQUIN | ||
|---|---|---|---|---|
| CAS Number | 71636-61-8 | Molecular Weight | 370.66900 | |
| Density | 1.299 g/cm3 | Boiling Point | 467.3ºC at 760 mmHg | |
| Molecular Formula | C16H17BrClNO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 236.4ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine.
PLoS ONE 8(3) , e57054, (2013) D1 and D2 receptor expressing striatal medium spiny neurons (MSNs) are ascribed to striatonigral ("direct") and striatopallidal ("indirect") pathways, respectively, that are believed to function antagonistically in motor control. Glutamatergic synaptic transm... |
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Developmental increase in D1-like dopamine receptor-mediated inhibition of glutamatergic transmission through P/Q-type channel regulation in the basal forebrain of rats.
Eur. J. Neurosci. 32(4) , 579-90, (2010) Whole-cell patch-clamp recordings of non-N-methyl-d-aspartate glutamatergic excitatory postsynaptic currents (EPSCs) were carried out from cholinergic neurons in slices of basal forebrain (BF) of developing rats aged 21-42 postnatal days to elucidate postnata... |
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Dopamine differentially modulates the excitability of striatal neurons of the direct and indirect pathways in lamprey.
J. Neurosci. 33(18) , 8045-54, (2013) The functions of the basal ganglia are critically dependent on dopamine. In mammals, dopamine differentially modulates the excitability of the direct and indirect striatal projection neurons, and these populations selectively express dopamine D1 and D2 recept... |
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Genetic reconstruction of dopamine D1 receptor signaling in the nucleus accumbens facilitates natural and drug reward responses.
J. Neurosci. 33(20) , 8640-9, (2013) The dopamine D1 receptor (D1R) facilitates reward acquisition and its alteration leads to profound learning deficits. However, its minimal functional circuit requirement is unknown. Using conditional reconstruction of functional D1R signaling in D1R knock-out... |
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Dopaminergic modulation of nitric oxide synthase activity in subregions of the rat nucleus accumbens.
Synapse 66(3) , 220-31, (2012) Nitric oxide (NO) is a gaseous neurotransmitter synthesized in the nucleus accumbens (NAc) by aspiny interneurons containing neuronal NO synthase (nNOS). nNOS activity is readily assayed using nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) s... |
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Dopamine receptor agonists: selectivity and dopamine D1 receptor efficacy.
Eur. J. Pharmacol. 188 , 335-347, (1990) Dopamine receptor selectivity was investigated for a number of dopamine receptor agonists. In vitro, the benzazepine derivatives, e.g., SKF 38393 and SKF 75670 as well as the isoquinoline derivatives, SKF 89626 and SKF 89615, were D1 receptor-selective. All o... |
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Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers.
J. Biol. Chem. 286(5) , 3270-6, (2011) Soluble oligomers of the amyloid-β peptide (AβOs) accumulate in the brains of Alzheimer disease (AD) patients and are implicated in synapse failure and early memory loss in AD. AβOs have been shown to impact synapse function by inhibiting long term potentiati... |
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Repeated exposure to MDMA and amphetamine: sensitization, cross-sensitization, and response to dopamine D₁- and D₂-like agonists.
Psychopharmacology 223(4) , 389-99, (2012) Acute exposure to (±) 3, 4-methylenedioxymethamphetamine (MDMA) produces hyperlocomotion that is preferentially expressed in the periphery of closed chambers. Following repeated administration, however, a sensitized hyperlocomotor response is preferentially e... |
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The tyrosine phosphatase Shp-2 interacts with the dopamine D(1) receptor and triggers D(1) -mediated Erk signaling in striatal neurons.
J. Neurochem. 117(2) , 253-63, (2011) We report a novel mechanism for dopamine D(1) receptor (D(1) R)-mediated extracellular signal-regulated kinases (Erk) activation in rat striatum. Erk signaling depends on phosphorylation and dephosphorylation events mediated by specific kinases and phosphatas... |